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Racial and Ethnic Differences in Liver Transplantation and Post–Liver Transplant Survival Among Patients With Hepatocellular Carcinoma
Journal article   Open access   Peer reviewed

Racial and Ethnic Differences in Liver Transplantation and Post–Liver Transplant Survival Among Patients With Hepatocellular Carcinoma

Udhayvir S. Grewal, Apoorva K. Chandar, Shiva J. Gaddam, Abdul Rahman Al Armashi, Akram Alkreshi and Subhash C. Garikipati
Cancer medicine (Malden, MA), Vol.13(21), e70298
11/06/2024
DOI: 10.1002/cam4.70298
PMCID: PMC11540875
PMID: 39506367
Appears in  UI Libraries Support Open Access
url
https://doi.org/10.1002/cam4.70298View
Published (Version of record) Open Access

Abstract

Background Racial and ethnic disparities in diagnosis and overall outcomes for HCC are well known. We present updated real-world data on racial or ethnic differences in LT and post-LT survival among patients with HCC in a large population-based database. Methods We used the TriNetX database to retrospectively identify patients who had HCC (ICD-10 C22.0, C22.8) and underwent LT (CPT codes 47,135, 47,140, 47,140, 47,141, 47,142) from 2012 to 2022 and compared outcomes across racial and ethnic subgroups. Results Majority of the patients were Caucasians (2403/2901, 84.8%), followed by African Americans (267/2901, 9.2%) Hispanic/Asian (231/2901, 7.9%). At follow up of 5 years, we noted no significant difference in mortality between AA and Caucasian patients [HR = 1.087 (95% CI 0.76, 1.56, p = 0.59)] as well as Hispanic/Asian and Caucasian patients [HR = 1.14 (95% CI 0.73, 1.78, p = 0.10)]. Conclusions These results indicate that stringent implementation of policies aimed at ensuring equitable access to LT may contribute to bridging disparities in overall outcomes in HCC.
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