Journal article
Racial and Ethnic Disparities in Phthalate Exposure and Preterm Birth: A Pooled Study of Sixteen U.S. Cohorts
Environmental health perspectives, Vol.131(12), 127015
12/01/2023
DOI: 10.1289/EHP12831
PMCID: PMC10732302
PMID: 38117586
Abstract
BACKGROUND: Phthalate exposuresareubiquitousduringpregnancyandmaycontributetoracialandethnicdisparitiesinpretermbirth. OBJECTIVES: We investigatedraceandethnicityintherelationshipbetweenbiomarkersofphthalateexposureandpretermbirthbyexamining: a) how hypotheticalreductionsinracialandethnicdisparitiesinphthalatemetabolitesmightreducetheprobabilityofpretermbirth; and b) exposureresponse modelsstratified byraceandethnicity. METHODS: We pooledindividual-leveldataon6,045pregnanciesfrom16U.S. cohorts. Weinvestigatedcovariate-adjusteddifferences innineurinary phthalate metaboliteconcentrationsbyraceandethnicity[non-HispanicWhite(White, 43%), non-HispanicBlack(Black, 13%), Hispanic/Latina38%), andAsian/Pacific Islander(3%)]. Usingg-computation, weestimatedchangesintheprobabilityofpretermbirthunderhypotheticalinterventions toeliminatedisparitiesinlevelsofurinaryphthalatemetabolitesbyproportionallyloweringaverageconcentrationsinBlackandHispanic/ Latina participantstobeapproximatelyequaltotheaveragesinWhiteparticipants. Wealsousedraceandethnicity-stratified logisticregressionto characterize associationsbetweenphthalatemetabolitesandpretermbirth. RESULTS: In comparisonwithconcentrationsamongWhiteparticipants, adjustedmeanphthalatemetaboliteconcentrationswereconsistentlyhigher among BlackandHispanic/Latinaparticipantsby23%-148% and4%-94%, respectively. Asian/Pacific Islanderparticipantshadmetabolitelevelsthat were similartothoseofWhiteparticipants. Hypotheticalinterventionstoreducedisparitiesinmetabolitemixtureswereassociatedwithlowerprobabilities ofpretermbirthforBlack[13% relativereduction; 95% confidence interval(CI): -34%, 8.6%] andHispanic/Latina(9% relativereduction; 95% CI: -19%, 0.8%) participants. Oddsratiosforpretermbirthinassociationwithphthalatemetabolitesdemonstratedheterogeneitybyraceand ethnicity fortwoindividualmetabolites(mono-n-butyl andmonoisobutylphthalate), withpositiveassociationsthatwerelargerinmagnitudeobserved among BlackorHispanic/Latinaparticipants. CONCLUSIONS: Phthalate metaboliteconcentrationsdiffered substantiallybyraceandethnicity. Ourresultsshowhypotheticalinterventionstoreduce population-level racialandethnicdisparitiesinbiomarkersofphthalateexposurecouldpotentiallyreducetheprobabilityofpretermbirth. https://doi.
Details
- Title: Subtitle
- Racial and Ethnic Disparities in Phthalate Exposure and Preterm Birth: A Pooled Study of Sixteen U.S. Cohorts
- Creators
- Barrett M. Welch - National Institute of Environmental Health SciencesAlexander P. Keil - National Cancer InstituteJessie P. Buckley - Johns Hopkins UniversityStephanie M. Engels - Univ North Carolina Chapel Hill, Chapel Hill, NC USATamarra James-Todd - Harvard UniversityAmi R. Zota - Columbia UniversityAkram N. Alshawabkeh - Northeastern UniversityEmily S. Barrett - Rutgers, The State University of New JerseyMichael S. Bloom - George Mason UniversityNicole R. Bush - University of California, San FranciscoJose F. Cordero - University of GeorgiaDana Dabelea - University of Colorado Anschutz Medical CampusBrenda Eskenazi - University of California, BerkeleyBruce P. Lanphear - Simon Fraser UniversityVasantha Padmanabhan - University of Michigan–Ann ArborSheela Sathyanarayana - Seattle Children's HospitalShanna H. Swan - Icahn School of Medicine at Mount SinaiJenny Aalborg - University of Colorado Anschutz Medical CampusDonna D. Baird - National Institute of Environmental Health SciencesAlexandra M. Binder - Cancer Center of HawaiiAsa Bradman - University of California, MercedJoseph M. Braun - Brown UniversityAntonia M. Calafat - National Center for Environmental HealthDavid E. Cantonwine - Brigham and Women's HospitalKate E. Christenbury - Social and Scientific SystemsPam Factor-Litvak - Columbia UniversityKim G. Harley - Center for Environmental HealthRuss Hauser - Harvard UniversityJulie B. Herbstman - Columbia UniversityIrva Hertz-Picciotto - Univ Calif Davis, Davis, CA USANina Holland - Center for Environmental HealthAnne Marie Z. Jukic - National Institute of Environmental Health SciencesThomas F. McElrath - Brigham and Women's HospitalJohn D. Meeker - University of Michigan–Ann ArborCarmen Messerlian - Harvard UniversityKarin B. Michels - University of California, Los AngelesRoger B. Newman - Medical University of South CarolinaRuby H. N. Nguyen - University of MinnesotaKatie M. O'Brien - Natl Inst Environm Hlth Sci, Res Triangle Pk, NC 27709 USAVirginia A. Rauh - Columbia UniversityBruce Redmon - University of MinnesotaDavid Q. Rich - University of Rochester Medical CenterEmma M. Rosen - University of North Carolina at Chapel HillRebecca J. Schmidt - University of California, DavisAmy E. Sparks - University of IowaAnne P. Starling - University of North Carolina at Chapel HillChristina Wang - Harbor–UCLA Medical CenterDeborah J. Watkins - University of Michigan–Ann ArborClarice R. Weinberg - National Institute of Environmental Health SciencesBarry Weinberger - Cohen Children's Medical CenterAbby G. Wenzel - Medical University of South CarolinaAllen J. Wilcox - National Institute of Environmental Health SciencesKimberly Yolton - Cincinnati Children's Hospital Medical CenterYu Zhang - Harvard UniversityKelly K. Ferguson - National Institute of Environmental Health SciencesPooled Phthalate Exposure
- Resource Type
- Journal article
- Publication Details
- Environmental health perspectives, Vol.131(12), 127015
- Publisher
- Us Dept Health Human Sciences Public Health Science
- DOI
- 10.1289/EHP12831
- PMID
- 38117586
- PMCID
- PMC10732302
- ISSN
- 0091-6765
- eISSN
- 1552-9924
- Number of pages
- 15
- Grant note
- ZIAES103321 / Intramural Research Program of the National Institutes of Health (NIH)/National Institute of Environmental Health Sciences (NIEHS); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) P30ES005022; UH30D023251; UH3OD023365; UH30D023342; R82670901; R827039 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R21CA128382 / National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) ULITR001881 / National Center for Advancing Translational Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) P42ES017198; P30ES005022; R21ES031231; P01ES009605; R24ES028529; R01ES021369; U24ES028529-06; R01ES024381; R01ES030078; R01ES022934; P30ES010126; P01 ES09584; R01ES013543; R01ES014393; R01ES08977 / NIEHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) ROlDK076648 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R21HD058019 / Eunice Kennedy Shriner National Institute of Child Health and Human Development
- Language
- English
- Date published
- 12/01/2023
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984577110202771
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