Racial and ethnic disparities in cardiometabolic disease and COVID-19 outcomes in White, Black/African American, and Latinx populations: Physiological underpinnings

Kanokwan Bunsawat; Gregory J. Grosicki; Soolim Jeong; Austin T. Robinson

doi:10.1016/j.pcad.2022.04.005

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Racial and ethnic disparities in cardiometabolic disease and COVID-19 outcomes in White, Black/African American, and Latinx populations: Physiological underpinnings

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Racial and ethnic disparities in cardiometabolic disease and COVID-19 outcomes in White, Black/African American, and Latinx populations: Physiological underpinnings

Kanokwan Bunsawat, Gregory J. Grosicki, Soolim Jeong and Austin T. Robinson

Progress in cardiovascular diseases, Vol.71, pp.11-19

03/01/2022

DOI: 10.1016/j.pcad.2022.04.005

PMCID: PMC9050188

PMID: 35490869

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Abstract

Coronavirus disease 2019 (COVID-19) is a highly contagious respiratory illness caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that began spreading globally in late 2019. While most cases of COVID-19 present with mild to moderate symptoms, COVID-19 was the third leading cause of mortality in the United States in 2020 and 2021. Though COVID-19 affects individuals of all races and ethnicities, non-Hispanic Black and Hispanic/Latinx populations are facing an inequitable burden of COVID-19 characterized by an increased risk for hospitalization and mortality. Importantly, non-Hispanic Black and Hispanic/Latinx adults have also faced a greater risk of non-COVID-19-related mortality (e.g., from cardiovascular disease/CVD) during the pandemic. Contributors to the racial disparities in morbidity and mortality during the pandemic are multi factorial as we discuss in our companion article on social determinants of health. However, profound racial variation in the prevalence of CVD and metabolic diseases may serve as a key driver of worse COVID-19-related and non-COVID-19-related health outcomes among racial and ethnic minority groups. Within this review, we provide data emphasizing the inequitable burden of CVD and metabolic diseases among non-Hispanic Black and Hispanic/Latinx populations. We also discuss the pathophysiology of these conditions, with a focus on how aberrant physiological alterations in the context of CVD and metabolic diseases manifest to increase susceptibility to severe COVID-19.(c) 2022 Elsevier Inc. All rights reserved.

Cardiac & Cardiovascular Systems

Cardiovascular System & Cardiology

Life Sciences & Biomedicine

Science & Technology

Details

Title: Subtitle: Racial and ethnic disparities in cardiometabolic disease and COVID-19 outcomes in White, Black/African American, and Latinx populations: Physiological underpinnings
Creators: Kanokwan Bunsawat - Geriatric Research Education and Clinical Center
Gregory J. Grosicki - Georgia Southern University
Soolim Jeong - Auburn University
Austin T. Robinson - Auburn University
Resource Type: Journal article
Publication Details: Progress in cardiovascular diseases, Vol.71, pp.11-19
DOI: 10.1016/j.pcad.2022.04.005
PMID: 35490869
PMCID: PMC9050188
NLM abbreviation: Prog Cardiovasc Dis
ISSN: 0033-0620
eISSN: 1873-1740
Publisher: Elsevier
Number of pages: 9
Grant note: K01 HL147998; T32 HL139451 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA T32HL139451 / National Heart Lung and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
Language: English
Date published: 03/01/2022
Academic Unit: Health, Sport, and Human Physiology
Record Identifier: 9984948046902771

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