Racial differences in cervical cytokine concentrations between pregnant women with and without bacterial vaginosis

Kelli K Ryckman; Scott M Williams; Marijane A Krohn; Hyagriv N Simhan

doi:10.1016/j.jri.2008.01.003

Back

Racial differences in cervical cytokine concentrations between pregnant women with and without bacterial vaginosis

Journal article

Peer reviewed

Racial differences in cervical cytokine concentrations between pregnant women with and without bacterial vaginosis

Kelli K Ryckman, Scott M Williams, Marijane A Krohn and Hyagriv N Simhan

Journal of reproductive immunology, Vol.78(2), pp.166-171

2008

DOI: 10.1016/j.jri.2008.01.003

PMCID: PMC2518392

PMID: 18336917

View Online

Abstract

We have examined the association between cervical cytokine, chemokine and growth factor concentrations with bacterial vaginosis (BV) in pregnant white and black women. A nested case–control analysis was performed to examine 28 cervical cytokine, chemokine and growth factor concentrations in 83 white women (55 with normal flora and 28 with BV) and 81 black women (39 with normal flora and 42 with BV). White women with BV had significantly lower IP10 ( P = 0.001) and MCP1 ( P = 0.006) concentrations compared to women with normal flora. Black women with BV had higher IL-1α ( P < 0.001) concentrations than those with normal flora. In women with normal flora, whites had significantly higher levels of IL-1α ( P = 0.047), IL-6 ( P = 0.010), IL-10 ( P = 0.016) and PDGF-BB ( P = 0.010) than blacks. There were no significant concentration differences between white and black women with BV. These results demonstrate significant differences in cytokine and chemokine concentrations between women with and without BV. Ethnic differences in cytokine concentrations were also observed in women with normal flora, indicating that white and black women with normal flora have different cytokine levels, but respond to BV in a similar manner.

Bacterial vaginosis

Cytokine levels

Ethnic differences

Details

Title: Subtitle: Racial differences in cervical cytokine concentrations between pregnant women with and without bacterial vaginosis
Creators: Kelli K Ryckman - Department of Medicine, Vanderbilt University, Nashville, TN, USA
Scott M Williams - Department of Medicine, Vanderbilt University, Nashville, TN, USA
Marijane A Krohn - Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Maternal-Fetal Medicine and Reproductive Infectious Diseases and Immunology, University of Pittsburgh School of Medicine, Magee-Womens Research Institute, Pittsburgh, PA, USA
Hyagriv N Simhan - Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Maternal-Fetal Medicine and Reproductive Infectious Diseases and Immunology, University of Pittsburgh School of Medicine, Magee-Womens Research Institute, Pittsburgh, PA, USA
Resource Type: Journal article
Publication Details: Journal of reproductive immunology, Vol.78(2), pp.166-171
DOI: 10.1016/j.jri.2008.01.003
PMID: 18336917
PMCID: PMC2518392
NLM abbreviation: J Reprod Immunol
ISSN: 0165-0378
eISSN: 1872-7603
Publisher: Elsevier Ireland Ltd
Language: English
Date published: 2008
Academic Unit: Stead Family Department of Pediatrics; Epidemiology
Record Identifier: 9984214725102771

Metrics

15 Record Views

29 Times Cited - Web of Science

See more details