Journal article
Radarins A-D: new antiinsectan and cytotoxic indole diterpenoids from the sclerotia of Aspergillus sulphureus
Journal of organic chemistry, Vol.57(1), pp.138-141
01/01/1992
DOI: 10.1021/jo00027a026
Abstract
Four new indole diterpenoids, radarins A-D (3-6), have been isolated from the sclerotia of Aspergillus sulphureus by chromatographic separation of the CH2Cl2 extract. The structure of radarin A (3) was determined using extensive high-field 2D NMR experiments. Radarins B-D (4-6) were assigned by analysis of NMR data, spectral comparison to 3, and/or by chemical interconversion. Compound 3 has the most potent activity against the corn earworm Helicoverpa zea and exhibits significant cytotoxicity in assays against three human solid tumor cell lines. © 1992, American Chemical Society. All rights reserved.
Details
- Title: Subtitle
- Radarins A-D: new antiinsectan and cytotoxic indole diterpenoids from the sclerotia of Aspergillus sulphureus
- Creators
- Jodi A LaaksoJames B GloerDonald T WicklowPatrick F Dowd
- Resource Type
- Journal article
- Publication Details
- Journal of organic chemistry, Vol.57(1), pp.138-141
- Publisher
- American Chemical Society
- DOI
- 10.1021/jo00027a026
- ISSN
- 0022-3263
- eISSN
- 1520-6904
- Language
- English
- Date published
- 01/01/1992
- Academic Unit
- Chemistry
- Record Identifier
- 9984216602702771
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