Radial artery tonometry demonstrates arterial stiffness in children with type 1 diabetes

Michael J Haller; Margaret Samyn; Wilmer W Nichols; Todd Brusko; Clive Wasserfall; R Fletcher Schwartz; Mark Atkinson; Jonathan J Shuster; Gary L Pierce; Janet H Silverstein

doi:10.2337/diacare.27.12.2911

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Radial artery tonometry demonstrates arterial stiffness in children with type 1 diabetes

Journal article

Peer reviewed

Radial artery tonometry demonstrates arterial stiffness in children with type 1 diabetes

Michael J Haller, Margaret Samyn, Wilmer W Nichols, Todd Brusko, Clive Wasserfall, R Fletcher Schwartz, Mark Atkinson, Jonathan J Shuster, Gary L Pierce and Janet H Silverstein

Diabetes care, Vol.27(12), pp.2911-2917

12/2004

DOI: 10.2337/diacare.27.12.2911

PMID: 15562206

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Abstract

To determine if children with type 1 diabetes have increased arterial stiffness by estimating augmentation index with the simple noninvasive technique of radial artery tonometry. We studied 98 type 1 diabetic children and 57 healthy control subjects, ages 10-18 years, matched for age, sex, race, and BMI, generating 43 matched pairs. Radial artery tonometry was performed, and blood was collected for analysis of fasting lipids, HbA1c, glucose, and cytokines in all children. Children with diabetes had a significantly higher augmentation index corrected to a heart rate of 75 (AI75) than their matched control subjects. Mean AI75 in type 1 diabetic subjects was 1.11 +/- 10.15 versus -3.32 +/- 10.36 in control subjects. The case-control difference was 5.20 +/- 11.02 (P=0.0031). Children with type 1 diabetes have increased arterial stiffness compared with healthy control subjects. Radial artery tonometry is a simple noninvasive technique that could be added to the armamentarium of tests used to provide cardiovascular risk stratification in children with type 1 diabetes.

Body Mass Index

Diabetes Mellitus, Type 1 - physiopathology

Humans

Male

Reference Values

Radial Artery - physiopathology

Peripheral Vascular Diseases - diagnosis

Peripheral Vascular Diseases - epidemiology

Adolescent

Diabetic Angiopathies - diagnosis

Diabetic Angiopathies - epidemiology

Female

Child

Manometry - methods

Details

Title: Subtitle: Radial artery tonometry demonstrates arterial stiffness in children with type 1 diabetes
Creators: Michael J Haller - Pediatric Endocrinology, P.O. Box 100296, Gainesville, FL 32610, USA. hallemj@peds.ufl.edu
Margaret Samyn
Wilmer W Nichols
Todd Brusko
Clive Wasserfall
R Fletcher Schwartz
Mark Atkinson
Jonathan J Shuster
Gary L Pierce
Janet H Silverstein
Resource Type: Journal article
Publication Details: Diabetes care, Vol.27(12), pp.2911-2917
Publisher: United States
DOI: 10.2337/diacare.27.12.2911
PMID: 15562206
ISSN: 0149-5992
eISSN: 1935-5548
Grant note: 39250-06 / PHS HHS 42288-05 / PHS HHS MO1-RR00082 / NCRR NIH HHS
Language: English
Date published: 12/2004
Academic Unit: Health and Human Physiology; Internal Medicine
Record Identifier: 9984002463102771

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