Radiation effects on retinal layers revealed by OCT, OCT-A, and perimetry as a function of dose and time from treatment

Michelle R Tamplin; Jui-Kai Wang; Elaine M Binkley; Mona K Garvin; Daniel E Hyer; John M Buatti; H Culver Boldt; Isabella M Grumbach; Randy H Kardon

doi:10.1038/s41598-024-53830-6

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Radiation effects on retinal layers revealed by OCT, OCT-A, and perimetry as a function of dose and time from treatment

Journal article

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Radiation effects on retinal layers revealed by OCT, OCT-A, and perimetry as a function of dose and time from treatment

Michelle R Tamplin, Jui-Kai Wang, Elaine M Binkley, Mona K Garvin, Daniel E Hyer, John M Buatti, H Culver Boldt, Isabella M Grumbach and Randy H Kardon

Scientific reports, Vol.14(1), 3380

02/09/2024

DOI: 10.1038/s41598-024-53830-6

PMCID: PMC10858219

PMID: 38336828

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Abstract

Optical coherence tomography (OCT) has become a key method for diagnosing and staging radiation retinopathy, based mainly on the presence of fluid in the central macula. A robust retinal layer segmentation method is required for identification of the specific layers involved in radiation-induced pathology in individual eyes over time, in order to determine damage driven by radiation injury to the microvessels and to the inner retinal neurons. Here, we utilized OCT, OCT-angiography, visual field testing, and patient-specific dosimetry models to analyze abnormal retinal layer thickening and thinning relative to microvessel density, visual function, radiation dose, and time from radiotherapy in a cross-sectional cohort of uveal melanoma patients treated with I-plaque brachytherapy. Within the first 24 months of radiotherapy, we show differential thickening and thinning of the two inner retinal layers, suggestive of microvessel leakage and neurodegeneration, mostly favoring thickening. Four out of 13 eyes showed decreased inner retinal capillary density associated with a corresponding normal inner retinal thickness, indicating early microvascular pathology. Two eyes showed the opposite: significant inner retinal layer thinning and normal capillary density, indicating early neuronal damage preceding a decrease in capillary density. At later time points, inner retinal thinning becomes the dominant pathology and correlates significantly with decreased vascularity, vision loss, and dose to the optic nerve. Stable multiple retinal layer segmentation provided by 3D graph-based methods aids in assessing the microvascular and neuronal response to radiation, information needed to target therapeutics for radiation retinopathy and vision loss.

Details

Title: Subtitle: Radiation effects on retinal layers revealed by OCT, OCT-A, and perimetry as a function of dose and time from treatment
Creators: Michelle R Tamplin - University of Iowa
Jui-Kai Wang - Iowa City VA Health Care System
Elaine M Binkley - University of Iowa
Mona K Garvin - Iowa City VA Health Care System
Daniel E Hyer - University of Iowa
John M Buatti - University of Iowa
H Culver Boldt - University of Iowa
Isabella M Grumbach - Iowa City VA Health Care System
Randy H Kardon - University of Iowa
Resource Type: Journal article
Publication Details: Scientific reports, Vol.14(1), 3380
DOI: 10.1038/s41598-024-53830-6
PMID: 38336828
PMCID: PMC10858219
NLM abbreviation: Sci Rep
eISSN: 2045-2322
Language: English
Date published: 02/09/2024
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Iowa Neuroscience Institute; Cardiovascular Medicine; Radiation Oncology; Neurosurgery; Otolaryngology; Internal Medicine; Ophthalmology and Visual Sciences
Record Identifier: 9984557955202771

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