Journal article
Radiation-induced changes in MR signal intensity and contrast enhancement of lumbosacral vertebrae: Do changes occur only inside the radiation therapy field?
Radiology, Vol.222(1), pp.179-183
2002
DOI: 10.1148/radiol.2221001808
PMID: 11756723
Abstract
Purpose: To evaluate temporal changes in signal intensity (SI) and degree of contrast enhancement (CE) of bone marrow in lumbosacral vertebrae inside and outside the radiation therapy (RT) field.
Materials and methods: Twenty-three patients with advanced uterine cervical cancer who were treated with RT were prospectively evaluated. Each patient underwent four dynamic magnetic resonance (MR) studies: before RT, 2 and 4 weeks after initiation of RT, and 4 weeks after completion of RT. SI and CE were calculated in all four studies of each patient.
Results: Bone marrow inside the RT field showed steady and marked increase in precontrast SI and early and transient increase in CE at 2 weeks after initiation of RT followed by progressive and marked decrease in CE at 4 weeks after initiation of RT and 4 weeks after completion of RT. Bone marrow outside the RT field showed slight increase in precontrast SI and steady and moderate decrease in CE to a lesser degree without early increase as seen in bone marrow inside the RT field.
Conclusion: RT causes an increase in precontrast SI predominantly in bone marrow inside the RT field. However, a decrease in CE is seen in bone marrow not only inside but also outside the RT field.
Details
- Title: Subtitle
- Radiation-induced changes in MR signal intensity and contrast enhancement of lumbosacral vertebrae: Do changes occur only inside the radiation therapy field?
- Creators
- Shoichiro OTAKE - Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, United StatesNina A MAYR - Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, United StatesToshihiro UEDA - Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, United StatesVincent A MAGNOTTA - Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, United StatesWilliam T. C YUH - Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, United States
- Resource Type
- Journal article
- Publication Details
- Radiology, Vol.222(1), pp.179-183
- Publisher
- Radiological Society of North America; Oak Brook, IL
- DOI
- 10.1148/radiol.2221001808
- PMID
- 11756723
- ISSN
- 0033-8419
- eISSN
- 1527-1315
- Language
- English
- Date published
- 2002
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984051767202771
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