Journal article
Radiation therapy improves survival for unresectable postpneumonectomy lung tumors
The Journal of surgical research, Vol.227, pp.60-66
07/01/2018
DOI: 10.1016/j.jss.2018.02.015
PMID: 29804863
Abstract
Background: Additional resection for cancer in the single lung is often considered a prohibitive risk. The role of radiation therapy (RT) in this patient population is less clear with very limited available data. In this study, we sought to examine patients with post-neumonectomy lung cancer not amenable to surgery, identify factors associated with receiving RT, and determine the impact of RT on survival outcomes.
Methods: The Surveillance, Epidemiology, and End Results (SEER) database (1988-2013) was queried for patients with inoperable contralateral lung cancer after pneumonectomy. Univariate and multivariate analyses were performed to identify factors associated with the receipt of RT. Survival outcomes were examined using the Kaplan-Meier method.
Results: In total, 191 patients with inoperable postpneumonectomy lung cancer were included. RT was delivered to 122 (63.9%) patients; 69 (36.1%) patients did not receive RT. On multivariate analysis, disease stage was identified as the only predictor associated with receipt of RT (P < 0.001). The median overall survival (OS) and disease-specific survival (DSS) for patients receiving RT were higher than those for patients who did not receive RT (25 versus 8 mo and 29 versus 10 mo, respectively; P < 0.001). Similarly, patients who received RT had a higher 3-y OS (34% versus 14%, P < 0.001) than those who did not receive RT. On subset analysis, survival benefit with RT was observed in patients with all tumor size groups, and there was a trend toward superior survival in patients with stage I/II disease, who received RT compared with those who did not. On multivariate Cox regression analysis, RT use was independently associated with decreased hazards of death after adjusting for other factors (HR, 0.539; P < 0.001).
Conclusions: Based on our analysis of the Surveillance, Epidemiology, and End Results (SEER) database, RT is associated with improved outcomes in inoperable patients with a contralateral lung cancer after pneumonectomy compared with observation alone. Published by Elsevier Inc.
Details
- Title: Subtitle
- Radiation therapy improves survival for unresectable postpneumonectomy lung tumors
- Creators
- Adil Ayub - The University of Texas Medical Branch at GalvestonSadiq Rehmani - Mount Sinai Health SystemAdnan M. Al-Ayoubi - Mt Sinai Hlth Syst, Icahn Sch Med, Dept Thorac Surg, New York, NY USAErik Lewis - Mt Sinai Hlth Syst, Icahn Sch Med, Dept Thorac Surg, New York, NY USANorberto Santana-Rodriguez - Mount Sinai Health SystemBernardino Clavo - Hospital Universitario de Gran Canaria Doctor NegrínWissam Raad - Mount Sinai Health SystemFaiz Y. Bhora - Mount Sinai Health System
- Resource Type
- Journal article
- Publication Details
- The Journal of surgical research, Vol.227, pp.60-66
- Publisher
- Elsevier
- DOI
- 10.1016/j.jss.2018.02.015
- PMID
- 29804863
- ISSN
- 0022-4804
- eISSN
- 1095-8673
- Number of pages
- 7
- Language
- English
- Date published
- 07/01/2018
- Academic Unit
- Cardiothoracic Surgery
- Record Identifier
- 9984701730802771
Metrics
4 Record Views