Journal article
Radical amino acid mutations persist longer in the absence of sex
Evolution, Vol.72(4), pp.808-824
04/2018
DOI: 10.1111/evo.13465
PMID: 29520921
Abstract
Harmful mutations are ubiquitous and inevitable, and the rate at which these mutations are removed from populations is a critical determinant of evolutionary fate. Closely related sexual and asexual taxa provide a particularly powerful setting to study deleterious mutation elimination because sexual reproduction should facilitate mutational clearance by reducing selective interference between sites and by allowing the production of offspring with different mutational complements than their parents. Here, we compared the rate of removal of conservative (i.e., similar biochemical properties) and radical (i.e., distinct biochemical properties) nonsynonymous mutations from mitochondrial genomes of sexual versus asexual Potamopyrgus antipodarum, a New Zealand freshwater snail characterized by coexisting and ecologically similar sexual and asexual lineages. Our analyses revealed that radical nonsynonymous mutations are cleared at higher rates than conservative changes and that sexual lineages eliminate radical changes more rapidly than asexual counterparts. These results are consistent with reduced efficacy of purifying selection in asexual lineages allowing harmful mutations to remain polymorphic longer than in sexual lineages. Together, these data illuminate some of the population‐level processes contributing to mitochondrial mutation accumulation and suggest that mutation accumulation could influence the outcome of competition between sexual and asexual lineages.
Details
- Title: Subtitle
- Radical amino acid mutations persist longer in the absence of sex
- Creators
- Joel Sharbrough - University of Iowa, BiologyMeagan Luse - University of Iowa, Ophthalmology and Visual SciencesJeffrey L Boore - Providence St. Joseph Health and Institute for Systems BiologyJohn M Logsdon - University of Iowa, BiologyMaurine Neiman - University of Iowa, Biology
- Resource Type
- Journal article
- Publication Details
- Evolution, Vol.72(4), pp.808-824
- DOI
- 10.1111/evo.13465
- PMID
- 29520921
- NLM abbreviation
- Evolution
- ISSN
- 0014-3820
- eISSN
- 1558-5646
- Number of pages
- 17
- Grant note
- Division of Molecular and Cellular Biosciences (1122176) National Science Foundation Iowa Academy of Sciences (IAS #13‐10) Division of Environmental Biology (1310825)
- Language
- English
- Date published
- 04/2018
- Academic Unit
- Gender, Women's and Sexuality Studies; Biology; Ophthalmology and Visual Sciences
- Record Identifier
- 9983991971802771
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