Journal article
Radiobromine production, isolation and radiosynthesis for the development of a novel prostate cancer radiotherapeutic agent
AIP conference proceedings, Vol.1845(1), 020007
WTTC16: Proceedings of the 16th International Workshop on Targetry and Target Chemistry
05/11/2017
DOI: 10.1063/1.4983538
Abstract
The radioactive isotopes of bromine accessible with low energy medical cyclotrons have unique potential for diagnostic and radiotherapeutic nuclear medicine applications. These include bromine-76 (t1/2 = 16 h) for positron emission tomography and bromine-77 (t1/2 = 57 h) for Auger radionuclide therapy. Methods are presented to synthesize NiSe discs from elemental starting materials for proton irradiation in a 4π water cooling target configuration. Radiobromide was isolated from the irradiated NiSe material by dry distillation and used to radiolabel 7α-BrDHT for investigation as an Androgen-receptor-targeted theranostic radiopharmaceutical.
Details
- Title: Subtitle
- Radiobromine production, isolation and radiosynthesis for the development of a novel prostate cancer radiotherapeutic agent
- Creators
- Paul A. Ellison - 2 Willmar Regional Cancer Center, 301 Becker Ave SW, Willmar, MN, 56201, United StatesStephen A. Graves - University of Wisconsin School of Medicine and Public HealthDhanabalan Murali - University of Wisconsin School of Medicine and Public HealthOnofre T. De Jesus - University of Wisconsin School of Medicine and Public HealthTodd E. Barnhart - University of Wisconsin School of Medicine and Public HealthBruce R. Thomadsen - University of Wisconsin School of Medicine and Public HealthTod Speer - 2 Willmar Regional Cancer Center, 301 Becker Ave SW, Willmar, MN, 56201, United StatesRobert J. Nickles - 2 Willmar Regional Cancer Center, 301 Becker Ave SW, Willmar, MN, 56201, United States
- Contributors
- Jonathan W. Engle (Editor) - Los Alamos National LaboratoryTodd E. Barnhart (Editor) - University of Wisconsin–MadisonFrancois M. Nortier (Editor) - Los Alamos National LaboratoryJames P. O’Neil (Editor) - Lawrence Berkeley LaboratoryEva R. Birnbaum (Editor) - Los Alamos National LaboratoryKatherine M. Gangon (Editor) - General Electric
- Resource Type
- Journal article
- Publication Details
- AIP conference proceedings, Vol.1845(1), 020007
- Conference
- WTTC16: Proceedings of the 16th International Workshop on Targetry and Target Chemistry
- DOI
- 10.1063/1.4983538
- eISBN
- 073541517X; 9780735415171
- ISSN
- 0094-243X
- eISSN
- 1551-7616
- Number of pages
- 7
- Language
- English
- Date published
- 05/11/2017
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Radiation Oncology
- Record Identifier
- 9984383892202771
Metrics
11 Record Views