Journal article
Radiofrequency Electromagnetic Fields Have No Effect on the In Vivo Proliferation of the 9L Brain Tumor
Radiation research, Vol.152(6), pp.665-671
12/1999
DOI: 10.2307/3580262
PMID: 10581537
Abstract
The intracranial 9L tumor model was used to determine if exposure to a radiofrequency (RF) electromagnetic field similar to those used in cellular telephone has any effects on the growth of a central nervous system tumor. Fischer 344 rats implanted with different numbers of 9L gliosarcoma cells were exposed to 835.62 MHz frequency-modulated continuous wave (FMCW) or 847.74 MHz code division multiple access (CDMA) RF field with nominal slot-average specific absorption rates in the brain of 0.75 ± 0.25 W/kg. The animals were exposed to the RF field for 4 h a day, 5 days a week starting 4 weeks prior to and up to 150 days after the implantation of tumor cells. Among sham-exposed animals injected with 2 to 10 viable cells (group 1), the median survival was 70 days, with 27% of the animals surviving at 150 days. The median survival length and final survival fraction for animals injected with 11 to 36 viable cells (group 2) were 52 days and 14%, respectively, while the values for those injected with 37 to 100 cells (group 3) were 45 days and 0%. The animals exposed to CDMA or FMCW had similar survival parameters, and the statistical comparison of the survival curves for each of the groups 1, 2 and 3 showed no significant differences compared to sham-exposed controls.
Details
- Title: Subtitle
- Radiofrequency Electromagnetic Fields Have No Effect on the In Vivo Proliferation of the 9L Brain Tumor
- Creators
- Ryuji Higashikubo - MallinckrodtVictoria O. Culbreth - Washington University in St. LouisDouglas R. Spitz - Washington University in St. LouisMarie C. LaRegina - Washington University in St. LouisWilliam F. Pickard - Washington University in St. LouisWilliam L. Straube - Rad Onc - Clinical DivisionsEduardo G. Moros - Washington University in St. LouisJoseph L Roti Roti - Washington University in St. Louis
- Resource Type
- Journal article
- Publication Details
- Radiation research, Vol.152(6), pp.665-671
- DOI
- 10.2307/3580262
- PMID
- 10581537
- ISSN
- 0033-7587
- eISSN
- 1938-5404
- Language
- English
- Date published
- 12/1999
- Academic Unit
- Pathology; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984312987402771
Metrics
9 Record Views