Journal article
Radiofrequency ablation compared to resection in early-stage hepatocellular carcinoma
HPB (Oxford, England), Vol.15(3), pp.210-217
03/01/2013
DOI: 10.1111/j.1477-2574.2012.00541.x
PMCID: PMC3572282
PMID: 23374361
Abstract
Objectives: This study aimed to compare survival outcomes after hepatic resection (HR) and radiofrequency ablation (RFA) in early-stage hepatocellular carcinoma (HCC) at a Western hepatobiliary centre. Methods: Demographic details, clinicopathologic tumour characteristics and survival outcomes were compared among non-transplant candidate patients undergoing HR (n= 50) and RFA (n= 60) for early-stage HCC during 20012011. Results: Patients who underwent HR had larger tumours, a longer length of stay and a higher rate of postoperative complications. After a median follow-up of 29months, there were no significant differences between the treatment groups in 1-, 3- and 5-year overall survival (OS) [RFA group: 86%, 50%, 35%, respectively; HR group: 88%, 68%, 47%, respectively (P= 0.222)] or disease-free survival (DFS) [RFA group: 68%, 42%, 28%, respectively; HR group: 66%, 42%, 34%, respectively (P= 0.823)]. The 58 patients who underwent RFA demonstrated ablation success on follow-up computed tomography at 3months. Of these, 96.5% of patients showed sustained ablation success over the entire follow-up period. In a subgroup analysis of patients with tumours measuring 25cm, no differences in OS or DFS emerged between the HR and RFA groups. Similarly, no significant differences in outcomes in patients with ChildPugh class A cirrhosis were seen between the RFA and HR groups. Conclusions: Radiofrequency ablation is comparable with HR in terms of OS and DFS. It is a reasonable alternative as a first-line treatment for HCC in well-selected patients who are not candidates for transplant.
Details
- Title: Subtitle
- Radiofrequency ablation compared to resection in early-stage hepatocellular carcinoma
- Creators
- Samer Tohme - University of PittsburghDavid A. Geller - University of PittsburghJon S. Cardinal - University of PittsburghHui-Wei Chen - University of PittsburghVignesh Packiam - University of PittsburghSrinevas Reddy - University of PittsburghJennifer Steel - University of PittsburghJames W. Marsh - University of PittsburghAllan Tsung - University of Pittsburgh
- Resource Type
- Journal article
- Publication Details
- HPB (Oxford, England), Vol.15(3), pp.210-217
- Publisher
- Elsevier
- DOI
- 10.1111/j.1477-2574.2012.00541.x
- PMID
- 23374361
- PMCID
- PMC3572282
- ISSN
- 1365-182X
- eISSN
- 1477-2574
- Number of pages
- 8
- Grant note
- T32AI074490 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) T32 AI074490 / NIAID NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Language
- English
- Date published
- 03/01/2013
- Academic Unit
- Urology
- Record Identifier
- 9984320852802771
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