Journal article
Radioimmunoscintigraphy with 111Indium Labeled Cyt-356 for the Detection of Occult Prostate Cancer Recurrence
The Journal of urology, Vol.152(5), pp.1490-1495
11/1994
DOI: 10.1016/S0022-5347(17)32453-9
PMID: 7523704
Abstract
We assessed the safety and ability of the 111indium labeled immunoconjugate 7E11-C5.3-glycyl-tyrosyl-(N, e-diethylenetriaminepentaacetic acid)-lysine (CYT-356) to detect sites of occult prostate cancer in 27 subjects who had undergone radical prostatectomy and whose only evidence of recurrent disease was an increasing (0.8 ng./ml. or greater) serum prostate specific antigen (PSA). All subjects underwent whole body scintigraphy between 2 and 4 days following the radiopharmaceutical injection. Routine blood work and human anti-mouse antibody titers were monitored. Scintigraphic findings were compared with clinical parameters, prostatic fossa biopsy results and conventional imaging techniques. Except for transient hypotension in 1 subject following the second infusion, no side effects or human anti-mouse antibody titers were detected. In 22 subjects 1 or more lesions were detected, of which 11 (50%) were confirmed by biopsy, computerized tomography or magnetic resonance imaging. Of 14 subjects with lesions in the prostatic fossa 13 had biopsies performed, 8 (62%) of which were positive. Magnetic resonance imaging confirmed tumor in the spine and chest computerized tomography findings were compatible with lesions seen in the mediastinum in 1 subject each. There was a statistically significant relationship between detecting a scan abnormality and the initial pathological stage of disease but not with the serum PSA. These data provide preliminary evidence that 111indium labeled CYT-356 can be safely administered and readministered, and it detects sites of occult prostate cancer recurrence in subjects whose PSA is increasing following radical prostatectomy.
Details
- Title: Subtitle
- Radioimmunoscintigraphy with 111Indium Labeled Cyt-356 for the Detection of Occult Prostate Cancer Recurrence
- Creators
- Daniel KahnRichard D WilliamsDavid W SeldinJohn A LibertinoMark HirschhornRobert DreicerGeorge J WeinerDavid BushnellJoseph Gulfo
- Resource Type
- Journal article
- Publication Details
- The Journal of urology, Vol.152(5), pp.1490-1495
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0022-5347(17)32453-9
- PMID
- 7523704
- ISSN
- 0022-5347
- eISSN
- 1527-3792
- Language
- English
- Date published
- 11/1994
- Academic Unit
- Radiology; Hematology, Oncology, and Blood & Marrow Transplantation; Pharmaceutical Sciences and Experimental Therapeutics; Internal Medicine
- Record Identifier
- 9984051532802771
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