Journal article
Radiologic and clinicopathologic characteristics of thyroid nodules with focal 68Ga-DOTATATE PET activity
Nuclear medicine communications, Vol.42(5), pp.510-516
05/2021
DOI: 10.1097/MNM.0000000000001356
PMID: 33481508
Abstract
Objective
Our aim was to determine the radiologic and clinicopathologic characteristics of thyroid nodules with focal 68Ga-DOTATATE activity.
Methods
In this retrospective study of 1927 consecutive 68Ga-DOTATATE PET scans, 85 patients with incidental and nonincidental focal 68Ga-DOTATATE avid thyroid nodules were identified, of which 31 patients with 33 thyroid nodules underwent fine-needle aspiration (FNA) or surgery. These 33 nodules were reviewed for Krenning score and SUVmax of the thyroid nodule, contralateral thyroid lobe and left atrium.
Results
Cytology/histopathology included 58% (19/33) with benign findings, 18% (6/33) medullary thyroid carcinoma (MTC), 9% (3/33) atypia or follicular lesion of undetermined significance (AUS/FLUS), 9% (3/33) suspicious for follicular neoplasm and Hurthle cell adenoma (SFN/HCA) and 6% (2/33) nondiagnostic cytology. Median serum calcitonin was 1156 pg/mL (range, 460–1828) in MTC and was <5.0 pg/mL (<5.0–12.5) in patients with benign nodules. Nodules had Krenning score of 1, 2 and 3 in 46% (15/33), 27% (9/33) and 27% (9/33). The majority of MTC and AUS/FLUS nodules had a Krenning score of 3, and there was substantial intragroup variation in Krenning score among the benign nodules. The mean SUVmax for the entire cohort was 5.5 ± 2.9 (mean ± SD), and the range was 2.0–13.0. There was overlap in the nodule/contralateral thyroid SUVmax ratios between groups. The MTC and AUS/FLUS nodules tended to have a higher nodule/blood pool SUVmax ratio than the other pathologic groups.
Conclusion
There was considerable variation in radiologic characteristics among benign thyroid nodules. The ratio of thyroid nodule SUVmax/blood pool SUVmax may be useful to differentiate pathologic groups, but larger studies are needed to investigate this further. Given the potential for malignancy in thyroid nodules with focal 68Ga-DOTATATE activity, further evaluation with serum calcitonin and FNA may be considered.
Video Abstract: http://links.lww.com/NMC/A186
Details
- Title: Subtitle
- Radiologic and clinicopathologic characteristics of thyroid nodules with focal 68Ga-DOTATATE PET activity
- Creators
- Jacob D. Kohlenberg - Mayo Clinic in ArizonaAnanya Panda - Mayo Clinic in ArizonaGeoffrey B. Johnson - Mayo ClinicM. Regina Castro - Mayo Clinic in Arizona
- Resource Type
- Journal article
- Publication Details
- Nuclear medicine communications, Vol.42(5), pp.510-516
- DOI
- 10.1097/MNM.0000000000001356
- PMID
- 33481508
- ISSN
- 0143-3636
- eISSN
- 1473-5628
- Language
- English
- Date published
- 05/2021
- Academic Unit
- Radiology
- Record Identifier
- 9984697631602771
Metrics
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