Journal article
Radiological findings following postsurgical intratumoral bleomycin injection for cystic craniopharyngioma
Clinical neurology and neurosurgery, Vol.109(3), pp.236-241
04/01/2007
DOI: 10.1016/j.clineuro.2006.09.002
PMID: 17046151
Abstract
Objectives
The purpose of this study was to compare the radiological findings before and after intratumoral bleomycin injection in patients with cystic craniopharyngioma so as to define the role of adjuvant intracavitary bleomycin chemotherapy for cystic craniopharyngiomas.
Patients and methods
Eleven patients whose craniopharyngioma was confirmed cytologically and/or histologically were retrospectively reviewed. The follow-up duration ranged from 9 to 79 months (mean, 31.6 months). Only the solid portion of the cystic craniopharyngiomas was excised before repeated injections of bleomycin (15–180 mg in total) into the cystic portion through an Ommaya reservoir were given. The patients were evaluated neuroradiologically before and after bleomycin administration.
Results
After the completion of all treatment cycles, the disappearance or shrinkage of the tumor was initially noted in all cases on follow-up CT and/or MR imaging studies. However, tumor recurrence was seen in four cases with a mixed tumor type.
Conclusion
Postoperative bleomycin injection in cystic craniopharyngioma does not appear to totally eradicate the tumor and does not stop tumor recurrence unless the cyst is the only portion of the craniopharyngioma that is left. Nevertheless, postoperative bleomycin injection decreases and stabilizes tumor size, and thus may be considered as an option of treatment modalities in patients with predominantly cystic craniopharyngiomas.
Details
- Title: Subtitle
- Radiological findings following postsurgical intratumoral bleomycin injection for cystic craniopharyngioma
- Creators
- Sang-Dae Kim - Korea UniversityJung-Yul Park - University of SeoulJuno Park - Korea UniversityJang-Bo Lee - Korea UniversitySe-Hoon Kim - Korea UniversityDong-Jun Lim - Korea University
- Resource Type
- Journal article
- Publication Details
- Clinical neurology and neurosurgery, Vol.109(3), pp.236-241
- Publisher
- Elsevier Science
- DOI
- 10.1016/j.clineuro.2006.09.002
- PMID
- 17046151
- ISSN
- 0303-8467
- eISSN
- 1872-6968
- Language
- English
- Date published
- 04/01/2007
- Academic Unit
- Neurosurgery
- Record Identifier
- 9984459634902771
Metrics
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