Journal article
Radiomic biomarkers informative of cancerous transformation in neurofibromatosis-1 plexiform tumors
Journal of neuroradiology, Vol.46(3), pp.179-185
05/2019
DOI: 10.1016/j.neurad.2018.05.006
PMCID: PMC6310110
PMID: 29958847
Abstract
This study explores whether objective, quantitative radiomic biomarkers derived from magnetic resonance (MR), positron emission tomography (PET), and computed tomography (CT) may be useful in reliably distinguishing malignant peripheral nerve sheath tumors (MPNST) from benign plexiform neurofibromas (PN).
A registration and segmentation pipeline was established using a cohort of NF1 patients with histopathological diagnosis of PN or MPNST, and medical imaging of the PN including MR and PET-CT. The corrected MR datasets were registered to the corresponding PET-CT via landmark-based registration. PET standard-uptake value (SUV) thresholds were used to guide segmentation of volumes of interest: MPNST-associated PET-hot regions (SUV≥3.5) and PN-associated PET-elevated regions (2.0<SUV<3.5). Quantitative imaging features were extracted from the MR, PET, and CT data and compared for statistical differences. Intensity histogram features included (mean, media, maximum, variance, full width at half maximum, entropy, kurtosis, and skewness), while image texture was quantified using Law's texture energy measures, grey-level co-occurrence matrices, and neighborhood grey-tone difference matrices.
For each of the 20 NF1 subjects, a total of 320 features were extracted from the image data. Feature reduction and statistical testing identified 9 independent radiomic biomarkers from the MR data (4 intensity and 5 texture) and 4 PET (2 intensity and 2 texture) were different between the PET-hot versus PET-elevated volumes of interest.
Our data suggests imaging features can be used to distinguish malignancy in NF1-realted tumors, which could improve MPNST risk assessment and positively impact clinical management of NF1 patients.
Details
- Title: Subtitle
- Radiomic biomarkers informative of cancerous transformation in neurofibromatosis-1 plexiform tumors
- Creators
- J Uthoff - Department of Radiology, University of Iowa, Iowa City, Iowa, United States of AmericaF.A De Stefano - Department of Radiology, University of Iowa, Iowa City, Iowa, United States of AmericaK Panzer - Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of AmericaB.W Darbro - Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of AmericaT.S Sato - Department of Radiology, University of Iowa, Iowa City, Iowa, United States of AmericaR Khanna - Department of Pharmacology, University of Arizona, Arizona, United States of AmericaD.E Quelle - Department of Pharmacology, University of Iowa, Iowa City, Iowa, United States of AmericaD.K Meyerholz - Department of Pathology, University of Iowa, Iowa City, Iowa, United States of AmericaJ Weimer - Pediatric and Rare Disease Group, Sanford Research, Sioux Falls, South Dakota, United States of AmericaJ.C Sieren - Department of Radiology, University of Iowa, Iowa City, Iowa, United States of America
- Resource Type
- Journal article
- Publication Details
- Journal of neuroradiology, Vol.46(3), pp.179-185
- DOI
- 10.1016/j.neurad.2018.05.006
- PMID
- 29958847
- PMCID
- PMC6310110
- NLM abbreviation
- J Neuroradiol
- ISSN
- 0150-9861
- eISSN
- 1773-0406
- Publisher
- Elsevier Masson SAS
- Language
- English
- Date published
- 05/2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Stead Family Department of Pediatrics; Pathology; Medical Genetics and Genomics; Neuroscience and Pharmacology
- Record Identifier
- 9984040356502771
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