Journal article
Radiomic profiling of high-risk aneurysms with blebs: an exploratory study
Journal of neurointerventional surgery, Vol.17(10), pp.1096-1101
10/2025
DOI: 10.1136/jnis-2024-022133
PMID: 39299742
Abstract
BackgroundBlebs significantly increase rupture risk of intracranial aneurysms. Radiomic analysis offers a robust characterization of the aneurysm wall. However, the unique radiomic profile of various compartments, including blebs, remains unexplored. Likewise, the correlation between these imaging markers and fluid/mechanical metrics is yet to be investigated. To address this, we analyzed the radiomic features (RFs) of bleb-containing aneurysms and their relationship with wall tension and shear stress metrics, aiming to enhance risk assessment.MethodsAneurysms were imaged using high-resolution magnetic resonance imaging (MRI). A T1 and a T1 after contrast (T1+Gd) sequences were acquired. 3D models of aneurysm bodies and blebs were generated, and RFs were extracted. Aneurysms with and without blebs were matched based on location and size for analysis. Univariate regression models and Spearman’s correlations were used to establish associations between bleb-dependent RFs and mechanical/fluid dynamics metrics.ResultsEighteen aneurysms with blebs were identified. Fifty-five RFs were significantly different between blebs and body within the same aneurysms. Of these RFs, 9% (5/55) were first-order, and 91% (50/55) were second-order features. After aneurysms with and without blebs were matched for location and size, five RFs 5% (5/93) were significantly different. Forty-one out of the 55 RFs different between bleb and body sac of the primary aneurysm were moderately and strongly correlated with mechanical and fluid dynamics metrics.ConclusionAneurysm blebs exhibit distinct radiomic profiles compared with the main body of the aneurysm sac. The variability in bleb wall characteristics may arise from differing mechanical stresses and localized hemodynamics. Leveraging radiomic profiling could help identify regions with a heightened risk of rupture.
Details
- Title: Subtitle
- Radiomic profiling of high-risk aneurysms with blebs: an exploratory study
- Creators
- Carlos Dier - Neurology, University of Iowa, Iowa City, Iowa, USASebastian Sanchez - University of New HavenElena Sagues - University of IowaAndres Gudino - University of IowaRodrigo Jaramillo - University of IowaLinder Wendt - University of IowaEdgar A Samaniego - Departments of Neurology, Neurosurgery and Radiology, University of Iowa, Iowa City, Iowa, USA
- Contributors
- Norma Beavers (Editor)
- Resource Type
- Journal article
- Publication Details
- Journal of neurointerventional surgery, Vol.17(10), pp.1096-1101
- DOI
- 10.1136/jnis-2024-022133
- PMID
- 39299742
- NLM abbreviation
- J Neurointerv Surg
- ISSN
- 1759-8478
- eISSN
- 1759-8486
- Publisher
- BMJ Publishing Group Ltd
- Grant note
- 1S10OD0250225-01 / Roy J. and Lucille A. Carver College of Medicine, University of Iowa (http://dx.doi.org/10.13039/100015515)
- Language
- English
- Electronic publication date
- 09/18/2024
- Date published
- 10/2025
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984704832702771
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