Journal article
Radiopeptide imaging and therapy in the United States
The Journal of nuclear medicine (1978), Vol.52 Suppl 2(2), pp.56S-63S
12/2011
DOI: 10.2967/jnumed.110.085746
PMID: 22144556
Abstract
Radiolabeled peptides targeted against receptors on the cell surface have been shown to be remarkably specific and effective in the diagnosis and therapy of malignant disease. Much of the early work in this field took place outside the United States, but in recent years the research effort within the United States has accelerated. Most of the initial studies in the United States focused on somatostatin receptor ligands. (111)In-pentetreotide was approved in 1994 and has been used extensively in the diagnosis and management of a wide variety of neuroendocrine tumors, particularly carcinoid. This work was extended to (99m)Tc-labeled analogs, and the most successful, (99m)Tc-depreotide, was approved in 1999. This agent was found to be accurate in the diagnosis of lung cancer, but it was not particularly successful because it was supplanted by (18)F-FDG imaging with positron tomography. More recently, studies with (68)Ga-labeled somatostatin analogs were initiated in the United States. This effort was delayed relative to that in other parts of the world because of difficulty in obtaining the necessary generators and regulatory uncertainty, both of which are less of a problem currently. Several ligands are being developed to image melanoma through targeting of the melanocyte-stimulating hormone receptor. Other ligands are being developed to use the arginine-glycine-aspartate oligopeptide to target angiogenesis and to use bombesin analogs to target the gastrin-releasing peptide receptor for the diagnosis and potential therapy of prostate cancer. Peptide dimers that target 2 receptors simultaneously are also being constructed, potentially increasing the selectivity of the approach significantly. Radiopeptide therapy has been explored with these ligands, initially with high-dose (111)In-pentetreotide. This step has been followed by U.S. participation in several trials with (90)Y-, (177)Lu-, and (188)Re-labeled analogs. Some of these agents are now available clinically outside the United States, and it is important to design and conduct the appropriate trials so that this therapy can be offered within the United States.
Details
- Title: Subtitle
- Radiopeptide imaging and therapy in the United States
- Creators
- Michael M Graham - Department of Radiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA. michael-graham@uiowa.eduYusuf Menda
- Resource Type
- Journal article
- Publication Details
- The Journal of nuclear medicine (1978), Vol.52 Suppl 2(2), pp.56S-63S
- Publisher
- United States
- DOI
- 10.2967/jnumed.110.085746
- PMID
- 22144556
- ISSN
- 0161-5505
- eISSN
- 1535-5667
- Language
- English
- Date published
- 12/2011
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984047673202771
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