Journal article
Radiopharmaceutical Delivery for Theranostics: Pharmacokinetics and Pharmacodynamics
Seminars in radiation oncology, Vol.31(1), pp.12-19
01/01/2021
DOI: 10.1016/j.semradonc.2020.07.009
PMID: 33246631
Abstract
Theranostics is a new and evolving combination diagnostic and/or therapeutic approach that is demonstrating efficacy for treatment of a growing number of cancers. In this approach, a diagnostic radiopharmaceutical is used in concert with positron-emission tomography (PET) or single photon emission computed tomography (SPECT) imaging to identify whether a cancer-specific membrane protein is strongly expressed on a patient's tumors. If the molecular target is detected with sufficient specificity and uptake, a therapeutic radiopharmaceutical, nearly identical to the diagnostic radiopharmaceutical except labeled with a longer-lived alpha or beta-emitting radionuclide, is administered at a therapeutic dose level to treat the cancer. Quantitative imaging methods are being used to elucidate patient-specific pharmacokinetics to select patients for whom the therapeutic radiopharmaceutical would be most beneficial. Similarly, quantitative imaging of the therapeutic radionuclide is being used to image pharmacodynamic response to therapy (cell kill) to guide personalized, patient-specific dosages designed to both reduce radiation toxicities and optimize radiotherapeutic benefit. (C) 2020 Published by Elsevier Inc.y
Details
- Title: Subtitle
- Radiopharmaceutical Delivery for Theranostics: Pharmacokinetics and Pharmacodynamics
- Creators
- John J. Sunderland - University of Iowa Hospitals and ClinicsLaura B. Ponto - University of Iowa Hospitals and ClinicsJacek Capala - Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD.
- Resource Type
- Journal article
- Publication Details
- Seminars in radiation oncology, Vol.31(1), pp.12-19
- Publisher
- Elsevier
- DOI
- 10.1016/j.semradonc.2020.07.009
- PMID
- 33246631
- ISSN
- 1053-4296
- eISSN
- 1532-9461
- Number of pages
- 8
- Language
- English
- Date published
- 01/01/2021
- Academic Unit
- Radiology; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984313069902771
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