Journal article
Radiopharmaceutical Stem Cell Tracking for Neurological Diseases
BioMed research international, Vol.2014(2014), pp.1-12
01/01/2014
DOI: 10.1155/2014/417091
PMCID: PMC4055613
PMID: 24982880
Abstract
Although neurological ailments continue to be some of the main causes of disease burden in the world, current therapies such as pharmacological agents have limited potential in the restoration of neural functions. Cell therapies, firstly applied to treat different hematological diseases, are now being investigated in preclinical and clinical studies for neurological illnesses. However, the potential applications and mechanisms for such treatments are still poorly comprehended and are the focus of permanent research. In this setting, noninvasive in vivo imaging allows better understanding of several aspects of stem cell therapies. Amongst the various methods available, radioisotope cell labeling has become one of the most promising since it permits tracking of cells after injection by different routes to investigate their biodistribution. A significant increase in the number of studies utilizing this method has occurred in the last years. Here, we review the different radiopharmaceuticals, imaging techniques, and findings of the preclinical and clinical reports published up to now. Moreover, we discuss the limitations and future applications of radioisotope cell labeling in the field of cell transplantation for neurological diseases.
Details
- Title: Subtitle
- Radiopharmaceutical Stem Cell Tracking for Neurological Diseases
- Creators
- Paulo Henrique Rosado-de-Castro - Universidade Federal do Rio de JaneiroPedro Moreno Pimentel-Coelho - Universidade Federal do Rio de JaneiroBianca Gutfilen - Universidade Federal do Rio de JaneiroSergio Augusto Lopes de Souza - Univ Fed Rio de Janeiro, Dept Radiol, Sch Med, Rio De Janeiro, RJ, BrazilGabriel Rodriguez de Freitas - Universidade Federal do Rio de JaneiroRosalia Mendez-Otero - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de JaneiroLea Mirian Barbosa da Fonseca - Univ Fed Rio de Janeiro, Dept Radiol, Sch Med, Rio De Janeiro, RJ, Brazil
- Resource Type
- Journal article
- Publication Details
- BioMed research international, Vol.2014(2014), pp.1-12
- DOI
- 10.1155/2014/417091
- PMID
- 24982880
- PMCID
- PMC4055613
- NLM abbreviation
- Biomed Res Int
- ISSN
- 2314-6133
- eISSN
- 2314-6141
- Publisher
- Hindawi Publishing Group
- Number of pages
- 12
- Grant note
- CNPq; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) Programa Ciencia Sem Fronteiras-CAPES Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)/Ministry of Science, Technology and Innovation.); Fundacao de Apoio a Pesquisa do Distrito Federal (FAPDF) CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)/Ministry of Education; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ); Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio De Janeiro (FAPERJ) Department of Science and Technology/(DECIT)/Ministry of Health; Department of Science & Technology (India)
- Language
- English
- Date published
- 01/01/2014
- Academic Unit
- Radiology
- Record Identifier
- 9985143123802771
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