Journal article
Radon, secondhand smoke, glutathione-S-transferase M1 and lung cancer among women
International journal of cancer, Vol.119(6), pp.1462-1467
2006
DOI: 10.1002/ijc.22002
PMID: 16642467
Abstract
Tobacco smoke and ionizing radiation induce oxidative stress by transmitting or generating reactive oxygen species (ROS). We hypothesized that glutathione-S-transferase M1 (GSTM1) null homozygotes would have decreased ability to neutralize ROS that might increase their susceptibility to lung cancer. A case-only design was used with lung cancer cases pooled from 3 previously completed case-control studies using archival tissue samples from 270 lung cancer cases to genotype GSTM1. Radon concentrations were measured with long-term α-track radon detectors. Second-hand smoke (SHS) was measured with questionnaires and interviews. Unconditional logistic regression was used to calculate the interaction odds ratios (OR) and 95% confidence intervals (95% CI). Radon concentrations >121 Bq m-3 were associated with a >3-fold interaction OR (OR = 3.41; 95% CI = 1.10, 10.61) for GSTM1 null homozygotes compared to GSTM1 carriers; the linear trend was significant (p trend = 0.03). The SHS and GSTM1 interaction OR was also elevated (OR = 2.28; 95% CI = 1.15-4.51) among never-smokers. This may be the first study to provide evidence of a GSTM1 and radon interaction in risk of lung cancer. Additionally, these findings support the hypothesis that radon and SHS promote neoplasia through shared elements of a common pathway. © 2006 Wiley-Liss, Inc.
Details
- Title: Subtitle
- Radon, secondhand smoke, glutathione-S-transferase M1 and lung cancer among women
- Creators
- Matthew R Bonner - University at Buffalo, State University of New YorkWilliam P Bennett - City Of Hope National Medical CenterWENYING Xiong - City Of Hope National Medical CenterQING Lan - United States Department of Health and Human ServicesRoss C Brownson - Saint Louis UniversityCurtis C Harris - United States Department of Health and Human ServicesR. William Field - University of IowaJay H Lubin - United States Department of Health and Human ServicesMichael C. R Alavanja - United States Department of Health and Human Services
- Resource Type
- Journal article
- Publication Details
- International journal of cancer, Vol.119(6), pp.1462-1467
- DOI
- 10.1002/ijc.22002
- PMID
- 16642467
- NLM abbreviation
- Int J Cancer
- ISSN
- 0020-7136
- eISSN
- 1097-0215
- Publisher
- Wiley-Liss
- Language
- English
- Date published
- 2006
- Academic Unit
- Occupational and Environmental Health; Epidemiology
- Record Identifier
- 9984364399202771
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