Journal article
Ragweed sensitization alters pulmonary vascular responses to bronchoprovocation in beagle dogs
Journal of applied physiology (1985), Vol.83(3), pp.912-917
09/01/1997
DOI: 10.1152/jappl.1997.83.3.912
PMID: 9292480
Abstract
Theodorou, Andreas, Natalie Weger, Kathleen Kunke, Kyoo Rhee, David Bice, Bruce Muggenberg, and Richard Lemen. Ragweed sensitization alters pulmonary vascular responses to bronchoprovocation in beagle dogs. J. Appl. Physiol.83(3): 912–917, 1997.—In ragweed (RW)-sensitized beagle dogs, we tested the hypothesis that reactivity of the pulmonary vasculature was enhanced with aerosolized histamine (Hist) and RW. Seven dogs were neonatally sensitized with repeated intraperitoneal RW injections, and 12 dogs were controls (Con). The dogs were anesthetized with intravenous chloralose, mechanically ventilated, and instrumented with femoral arterial and pulmonary artery catheters. Specific lung compliance (Cl sp), specific lung conductance (Gsp), systemic vascular resistance index, and pulmonary vascular resistance index (PVRI) were measured before and after bronchoprovocation with Hist and RW. After Hist inhalation (5 breaths of 30 mg/ml), both Con and RW dogs had significant ( P < 0.05) decreases in Cl sp(−51 ± 4 and −53 ± 5%, respectively) and Gsp (−65 ± 5 and −69 ± 3%, respectively), but only RW-sensitized dogs had a significant increase in PVRI (38 ± 10%). After RW inhalation (60 breaths of 0.8 mg/ml), only RW-sensitized dogs had significant increases (62 ± 20%) in PVRI and decreases in Gsp (−77 ± 4%) and Cl sp(−65 ± 7%). We conclude that, compared with Con, RW-sensitized beagle dogs have increased pulmonary vasoconstrictive responses with Hist or RW inhalation.
Details
- Title: Subtitle
- Ragweed sensitization alters pulmonary vascular responses to bronchoprovocation in beagle dogs
- Creators
- Andreas Theodorou - Respiratory Sciences Center and Steele Memorial Children’s Research Center, University of Arizona, Tucson, Arizona 85724-5073; andNatalie Weger - Respiratory Sciences Center and Steele Memorial Children’s Research Center, University of Arizona, Tucson, Arizona 85724-5073; andKathleen Kunke - Respiratory Sciences Center and Steele Memorial Children’s Research Center, University of Arizona, Tucson, Arizona 85724-5073; andKyoo Rhee - Respiratory Sciences Center and Steele Memorial Children’s Research Center, University of Arizona, Tucson, Arizona 85724-5073; andDavid Bice - Inhalation Toxicology Research Institute, Albuquerque, New Mexico 87115Bruce Muggenberg - Inhalation Toxicology Research Institute, Albuquerque, New Mexico 87115Richard Lemen - Respiratory Sciences Center and Steele Memorial Children’s Research Center, University of Arizona, Tucson, Arizona 85724-5073; and
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.83(3), pp.912-917
- DOI
- 10.1152/jappl.1997.83.3.912
- PMID
- 9292480
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Language
- English
- Date published
- 09/01/1997
- Academic Unit
- Surgery
- Record Identifier
- 9984051580202771
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