Journal article
Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission
Virology (New York, N.Y.), Vol.318(1), pp.17-23
01/05/2004
DOI: 10.1016/j.virol.2003.09.028
PMID: 14972530
Abstract
A number of studies examining interactions of dendritic cell (DC)-specific ICAM-3 grabbing nonintegrin (DC-SIGN) with viral pathogens have relied on monocytic transfectants as models for primary DCs. Here we show that the presumed "THP-1" monocytic cells used in these studies are instead Raji B cells. Moreover, we demonstrate that true THP-1 cells do not support DC-SIGN-mediated HIV-1 transmission, whereas human B cell lines efficiently enhance this process. These data indicate that there are features common to B cells and DCs that facilitate transmission of HIV-1 and provide new insights toward the mechanism of DC-SIGN-mediated HIV-1 transmission.
Details
- Title: Subtitle
- Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission
- Creators
- Li Wu - Model Development Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USAThomas D MartinMary CarringtonVineet N KewalRamani
- Resource Type
- Journal article
- Publication Details
- Virology (New York, N.Y.), Vol.318(1), pp.17-23
- DOI
- 10.1016/j.virol.2003.09.028
- PMID
- 14972530
- NLM abbreviation
- Virology
- ISSN
- 0042-6822
- eISSN
- 1096-0341
- Publisher
- United States
- Grant note
- N01-CO-12400 / NCI NIH HHS
- Language
- English
- Date published
- 01/05/2004
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984001160502771
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