Journal article
Randomized Comparison of Oral Valacyclovir and Intravenous Ganciclovir for Prevention of Cytomegalovirus Disease after Allogeneic Bone Marrow Transplantation
Clinical infectious diseases, Vol.36(6), pp.749-758
03/15/2003
DOI: 10.1086/367836
PMID: 12627359
Abstract
In this multicenter, randomized study, cytomegalovirus (CMV)-seropositive patients who received an allogeneic bone marrow transplant were provided high-dose intravenous acyclovir (500 mg/m2 q8h) from the day of transplantation until engraftment. The patients were then randomly assigned to receive either oral valacyclovir, 2 g q.i.d. (n = 83), or intravenous ganciclovir, 5 mg/kg q12h for 1 week, then 6 mg/kg once daily for 5 days per week (n = 85), until day 100 after transplantation. CMV infection occurred in 12% of the patients who received valacyclovir and in 19% of the patients who received ganciclovir (hazard ratio [HR], 1.042; 95% confidence interval [CI], 0.391–2.778; P =.934). CMV disease developed in only 2 patients who received valacyclovir and in 1 patient who received ganciclovir (HR, 1.943; 95% CI, 0.176–21.44; P =.588). Oral valacyclovir can be an effective alternative to intravenous ganciclovir for prophylaxis of CMV disease after bone marrow transplantation.
Details
- Title: Subtitle
- Randomized Comparison of Oral Valacyclovir and Intravenous Ganciclovir for Prevention of Cytomegalovirus Disease after Allogeneic Bone Marrow Transplantation
- Creators
- Drew J Winston - University of California, Los Angeles, Center for the Health Sciences, Los AngelesAndrew M Yeager - Emory University Cancer Center, Atlanta, GeorgiaPranatharthi H Chandrasekar - Harper Hospital, Wayne State University, Detroit, MichiganDavid R Snydman - Tufts-New England Medical Center, Boston, MassachusettsFinn Bo Petersen - University of Utah Hospital, Salt Lake City, UtahMary C Territo - University of California, Los Angeles, Center for the Health Sciences, Los AngelesValacyclovir Cytomegalovirus Study Group
- Contributors
- Margarida Magalhaes-Silverman (Contributor) - University of Iowa, Internal Medicine
- Resource Type
- Journal article
- Publication Details
- Clinical infectious diseases, Vol.36(6), pp.749-758
- Publisher
- The University of Chicago Press
- DOI
- 10.1086/367836
- PMID
- 12627359
- ISSN
- 1058-4838
- eISSN
- 1537-6591
- Language
- English
- Date published
- 03/15/2003
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984094485002771
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