Randomized Controlled Study of Cooled vs Room-Temperature Artificial Tears for Reducing Ocular Surface Irritation After Intravitreal Injection

Smrithi Mani; Haoxing D. Jin; Bryce Shonka; Christopher R. Fortenbach; Jonathan F. Russell

doi:10.1177/24741264231175555

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Randomized Controlled Study of Cooled vs Room-Temperature Artificial Tears for Reducing Ocular Surface Irritation After Intravitreal Injection

Journal article

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Randomized Controlled Study of Cooled vs Room-Temperature Artificial Tears for Reducing Ocular Surface Irritation After Intravitreal Injection

Smrithi Mani, Haoxing D. Jin, Bryce Shonka, Christopher R. Fortenbach and Jonathan F. Russell

Journal of VitreoRetinal Diseases, Vol.7(4), pp.310-315

07/2023

DOI: 10.1177/24741264231175555

PMCID: PMC10621712

PMID: 37927318

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10621712/pdf/10.1177_24741264231175555.pdfView

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Abstract

Purpose: To evaluate the efficacy of cooled vs room-temperature artificial tears in reducing ocular discomfort after intravitreal injections (IVIs). Methods: Patients receiving a standard intravitreal injection in the retina clinic who met the eligibility criteria and provided informed consented were enrolled in the study. Patients were randomized to the cooled tears or room-temperature tears intervention group. Both groups rated their ocular discomfort following IVI after cooled or room-temperature tears were administered. Results: The cooled group comprised 48 patients and the room-temperature group, 61 patients. There was no significant difference in the reduction of ocular discomfort between the cooled vs room-temperature artificial tears groups (P = .387). In addition, there was a similar level of reduction in ocular discomfort after either intervention (P = .681) regardless of whether or not the patients routinely used artificial tears after previous IVIs. Conclusions: Cooled tears provided no additional benefit in reducing ocular discomfort post-IVI compared with room-temperature tears. Baseline tear use after an IVI may have no true benefit other than a potential placebo effect, recall bias, or both.

randomized controlled study

ocular discomfort

intravitreal injection

surface irritation

cooled tears

Details

Title: Subtitle: Randomized Controlled Study of Cooled vs Room-Temperature Artificial Tears for Reducing Ocular Surface Irritation After Intravitreal Injection
Creators: Smrithi Mani - University of Iowa
Haoxing D. Jin - University of Iowa
Bryce Shonka - University of Iowa
Christopher R. Fortenbach - University of Iowa
Jonathan F. Russell - University of Iowa
Resource Type: Journal article
Publication Details: Journal of VitreoRetinal Diseases, Vol.7(4), pp.310-315
DOI: 10.1177/24741264231175555
PMID: 37927318
PMCID: PMC10621712
NLM abbreviation: J Vitreoretin Dis
ISSN: 2474-1264
eISSN: 2474-1272
Publisher: SAGE Publications
Language: English
Electronic publication date: 05/18/2023
Date published: 07/2023
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9984410800802771

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