Journal article
Randomized Multicenter Clinical Trial of Myofascial Physical Therapy in Women with Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS) and Pelvic Floor Tenderness
The Journal of urology, Vol.187(6), pp.2113-2118
06/01/2012
DOI: 10.1016/j.juro.2012.01.123
PMCID: PMC3351550
PMID: 22503015
Abstract
Purpose:
We determined the efficacy and safety of pelvic floor myofascial physical therapy compared to global therapeutic massage in women with newly symptomatic interstitial cystitis/painful bladder syndrome.
Materials and Methods:
A randomized controlled trial of 10 scheduled treatments of myofascial physical therapy vs global therapeutic massage was performed at 11 clinical centers in North America. We recruited women with interstitial cystitis/painful bladder syndrome with demonstrable pelvic floor tenderness on physical examination and a limitation of no more than 3 years' symptom duration. The primary outcome was the proportion of responders defined as moderately improved or markedly improved in overall symptoms compared to baseline on a 7-point global response assessment scale. Secondary outcomes included ratings for pain, urgency and frequency, the O'Leary-Sant IC Symptom and Problem Index, and reports of adverse events. We compared response rates between treatment arms using the exact conditional version of the Mantel-Haenszel test to control for clustering by clinical center. For secondary efficacy outcomes cross-sectional descriptive statistics and changes from baseline were calculated.
Results:
A total of 81 women randomized to the 2 treatment groups had similar symptoms at baseline. The global response assessment response rate was 26% in the global therapeutic massage group and 59% in the myofascial physical therapy group (p = 0.0012). Pain, urgency and frequency ratings, and O'Leary-Sant IC Symptom and Problem Index decreased in both groups during followup, and were not significantly different between the groups. Pain was the most common adverse event, occurring at similar rates in both groups. No serious adverse events were reported.
Conclusions:
A significantly higher proportion of women with interstitial cystitis/painful bladder syndrome responded to treatment with myofascial physical therapy than to global therapeutic massage. Myofascial physical therapy may be a beneficial therapy in women with this syndrome.
Details
- Title: Subtitle
- Randomized Multicenter Clinical Trial of Myofascial Physical Therapy in Women with Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS) and Pelvic Floor Tenderness
- Creators
- M P FitzgeraldCk PayneEs LukaczCc YangKm PetersTc ChaiJc NickelPm HannoKj KrederDa BurksR. Mayer - University of Rochester Medical CenterR. Kotarinos - Loyola University Medical CenterC. Fortman - Loyola University Medical CenterTm AllenL. Fraser - University of California San DiegoM. Mason-Cover - University of WashingtonC. FureyL. Odabachian - Beaumont Hospital, TroyA. Sanfield - Beaumont Hospital, TroyJ. Chu - University of Maryland, BaltimoreK. Huestis - University of Maryland, BaltimoreGe TataN. Dugan - University of Pennsylvania Health SystemH. Sheth - University of Pennsylvania Health SystemK. Bewyer - University of Iowa Hospitals and ClinicsA. Anaeme - Henry Ford HospitalK. Newton - Henry Ford HospitalW. Featherstone - University of Rochester Medical CenterR. Halle-Podell - Massage Therapy of Oak Park, Oak Park, IllinoisL. Cen - University of PennsylvaniaJr Landis - University of PennsylvaniaKj PropertHe FosterJw KusekLm Nyberg - National Institute of Diabetes and Digestive and Kidney DiseasesInterstitial Cystitis Collaborative Research Network
- Resource Type
- Journal article
- Publication Details
- The Journal of urology, Vol.187(6), pp.2113-2118
- DOI
- 10.1016/j.juro.2012.01.123
- PMID
- 22503015
- PMCID
- PMC3351550
- NLM abbreviation
- J Urol
- ISSN
- 0022-5347
- eISSN
- 1527-3792
- Language
- English
- Date published
- 06/01/2012
- Academic Unit
- Obstetrics and Gynecology; Urology
- Record Identifier
- 9984383888902771
Metrics
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