Journal article
Randomized controlled trial comparing the Franseen needle with the Fork-tip needle for EUS-guided fine-needle biopsy
Gastrointestinal endoscopy, Vol.93(1), pp.140-150.e2
01/2021
DOI: 10.1016/j.gie.2020.05.057
PMID: 32526235
Abstract
EUS-guided FNA primarily provides cytologic samples. EUS-guided fine-needle biopsy (FNB) with needles that provide histologic specimens may enhance diagnostic yield and facilitate accessory tissue staining. Several different needle designs are currently available and design superiority is unknown. We designed a randomized controlled trial to compare 2 commonly used EUS-FNB needles in their ability to provide histologic tissue samples (primary endpoint) and to reach an accurate diagnosis (secondary endpoint).
A total of 150 lesions from 134 patients (November 2018 to June 2019) were randomized 1:1 between biopsy with a Franseen needle and a Fork-tip needle. The groups were compared regarding the quality of the tissue samples and diagnostic accuracy.
Of 150 lesions, 75 were pancreatic and 75 were other solid lesions in and around the GI tract. There was no statistically significant difference between the Franseen needle and the Fork-tip needle in the yield of adequate histologic samples, 71 of 75 (94.7%) versus 72 of 75 (96%), (P = 1.00), an absolute difference of −1.3% (95% confidence interval [CI], −8.1% to 5.4%). The 2 groups were similar in the diagnostic accuracy of histologic analysis, 64 of 75 (85.3%) versus 68 of 75 (90.7%) (P = .45), absolute difference −5.4% (95% CI, −15.7% to 5%); and in the diagnostic accuracy of combined cytologic and histologic analysis, 65 of 75 (86.7%) versus 69 of 75 (92%) (P = .43), absolute difference −5.3% (95% CI, −15.2% to 4.5%).
There was no significant difference in the performance of the Franseen needle versus the Fork-tip needle. Both needles achieved a high yield of histologic tissue samples and high diagnostic accuracy. (Clinical trial registration number: NCT03672032.)
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Details
- Title: Subtitle
- Randomized controlled trial comparing the Franseen needle with the Fork-tip needle for EUS-guided fine-needle biopsy
- Creators
- Munish Ashat - University of Iowa Hospitals and ClinicsJagpal S Klair - University of Iowa Hospitals and ClinicsSydney L Rooney - University of Iowa Hospitals and ClinicsSagar J Vishal - University of Iowa Hospitals and ClinicsChris Jensen - University of Iowa Hospitals and ClinicsNadav Sahar - University of Iowa Hospitals and ClinicsArvind R Murali - University of Iowa Hospitals and ClinicsRami El-Abiad - University of Iowa Hospitals and ClinicsHenning Gerke - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Gastrointestinal endoscopy, Vol.93(1), pp.140-150.e2
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.gie.2020.05.057
- PMID
- 32526235
- ISSN
- 0016-5107
- eISSN
- 1097-6779
- Language
- English
- Date published
- 01/2021
- Academic Unit
- Gastroenterology and Hepatology; Pathology; Internal Medicine
- Record Identifier
- 9984186565402771
Metrics
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