Journal article
Randomized controlled trial of twice-daily versus alternate-day oral iron therapy in the treatment of iron-deficiency anemia
Annals of hematology, Vol.99(1), pp.57-63
01/2020
DOI: 10.1007/s00277-019-03871-z
PMID: 31811360
Abstract
Recent studies in iron-depleted women have challenged the current approach of treating iron-deficiency anemia (IDA) with oral iron in divided daily doses. Alternate day dosing leads to more fractional absorption of iron. In this randomized controlled trial, we looked at the efficacy and safety of alternate-day (AD) versus twice-daily (BD) oral iron in all severity of IDA. Total of 62 patients were randomized, 31 patients in BD arm received 60 mg elemental iron twice daily while 31 patients in AD arm received 120 mg iron on alternate days. The primary endpoint of 2 g/dl rise in hemoglobin was met in significantly more patients in the BD arm at 3 weeks (32.3% vs. 6.5%, p < 0.0001) and 6 weeks (58% vs. 35.5%, p = 0.001). There was a significant rise in the median hemoglobin at 3 (1.6 vs. 1.1, p = 0.02) and 6 weeks (2.9 vs. 2.0 g/dl, p = 0.03) in the BD arm. However, the median hemoglobin rise in the AD arm at 6 weeks was not significantly different than the BD arm at 3 weeks. Alternate-day dosing for 6 weeks and twice-daily dosing for 3 weeks resulted in the provision of the same total amount of iron. There were more reports of nausea in the BD arm (p = 0.03). In conclusion, the choice of twice-daily or alternate-day oral iron therapy should depend on the severity of anemia, the rapidity of response desired, and patient preference to either regimen due to adverse events. Trial Registration: CTRI reg. no. CTRI/2018/07/015106 http://ctri.nic.in/Clinicaltrials/login.php.
Details
- Title: Subtitle
- Randomized controlled trial of twice-daily versus alternate-day oral iron therapy in the treatment of iron-deficiency anemia
- Creators
- Rahul Kaundal - Post Graduate Institute of Medical Education and ResearchPrateek Bhatia - Post Graduate Institute of Medical Education and ResearchArihant Jain - Post Graduate Institute of Medical Education and ResearchAnkur Jain - Post Graduate Institute of Medical Education and ResearchRam V Nampoothiri - Post Graduate Institute of Medical Education and ResearchKundan Mishra - Post Graduate Institute of Medical Education and ResearchAditya Jandial - Post Graduate Institute of Medical Education and ResearchDeepak Goni - Post Graduate Institute of Medical Education and ResearchRajeev Sandal - Post Graduate Institute of Medical Education and ResearchNishant Jindal - Post Graduate Institute of Medical Education and ResearchAshok Meshram - Post Graduate Institute of Medical Education and ResearchRintu Sharma - Post Graduate Institute of Medical Education and ResearchNiranjan Khaire - Post Graduate Institute of Medical Education and ResearchCharanpreet Singh - Post Graduate Institute of Medical Education and ResearchAlka Khadwal - Post Graduate Institute of Medical Education and ResearchGaurav Prakash - Post Graduate Institute of Medical Education and ResearchReena Das - Post Graduate Institute of Medical Education and ResearchNeelam Varma - Post Graduate Institute of Medical Education and ResearchSubhash Varma - Post Graduate Institute of Medical Education and ResearchPankaj Malhotra - Post Graduate Institute of Medical Education and ResearchDeepesh P Lad - Post Graduate Institute of Medical Education and Research
- Resource Type
- Journal article
- Publication Details
- Annals of hematology, Vol.99(1), pp.57-63
- DOI
- 10.1007/s00277-019-03871-z
- PMID
- 31811360
- ISSN
- 0939-5555
- eISSN
- 1432-0584
- Grant note
- IM/2018/99 / Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, India.
- Language
- English
- Date published
- 01/2020
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985237609602771
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