Journal article
Randomized study of prophylactic platelet transfusion threshold during induction therapy for adult acute leukemia: 10,000/microL versus 20,000/microL
Journal of clinical oncology, Vol.15(3), pp.1143-1149
03/1997
DOI: 10.1200/JCO.1997.15.3.1143
PMID: 9060557
Abstract
We designed and conducted a randomized single-institution trial comparing two common prophylactic platelet transfusion thresholds in patients undergoing induction therapy for acute leukemia. Seventy-eight patients undergoing induction therapy for acute leukemia were randomized to receive prophylactic apheresis platelet concentrates when the platelet count was either < or = 10,000/microL or < or = 20,000/microL. There was no significant difference in the total number of bleeding episodes per patient with a median of four in the < or = 10,000/microL arm and two in the < or = 20,000/microL arm (25th to 75th percentiles of 2, 7 and 1, 5, respectively; P = .12). Patients randomized to the < or = 10,000/microL arm received more platelet transfusions for bleeding [one (0, 2) v zero (0, 0); P = .0003]. In contrast, patients on the < or = 20,000/microL arm received more platelet transfusions for prophylactic indications [10 (5, 14) v six (3, 8); P = 0.001], as would be expected, but less for bleeding. Nevertheless, the total number of platelet transfusions given to patients on the < or = 20,000/microL arm was higher and nearly significant [11 (6, 15) v seven (5, 11); P = .07]. There were no statistically significant differences between the groups with regard to RBC transfusion requirements, febrile days, days hospitalized, days thrombocytopenic, need for HLA-matched platelets, remission rate, or death during induction chemotherapy. No patient in either group died from hemorrhage or underwent major surgery for bleeding complications. Giving prophylactic platelets at a threshold of < or = 10,000/microL compared with < or = 20,000/microL can decrease the total utilization of platelets with only a small adverse effect on bleeding, and no statistically significant effect on morbidity.
Details
- Title: Subtitle
- Randomized study of prophylactic platelet transfusion threshold during induction therapy for adult acute leukemia: 10,000/microL versus 20,000/microL
- Creators
- K D Heckman - Department of Medicine, The University of Iowa College of Medicine, Iowa City 52242, USAG J WeinerC S DavisR G StraussM P JonesC P Burns
- Resource Type
- Journal article
- Publication Details
- Journal of clinical oncology, Vol.15(3), pp.1143-1149
- Publisher
- United States
- DOI
- 10.1200/JCO.1997.15.3.1143
- PMID
- 9060557
- ISSN
- 0732-183X
- eISSN
- 1527-7755
- Language
- English
- Date published
- 03/1997
- Academic Unit
- Statistics and Actuarial Science; Hematology, Oncology, and Blood & Marrow Transplantation; Pharmaceutical Sciences and Experimental Therapeutics; Biostatistics; Public Policy Center (Archive); Internal Medicine
- Record Identifier
- 9983985920302771
Metrics
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