Randomized trial of cognitive speed of processing training in Parkinson disease

Jerri D EDWARDS; Robert A HAUSER; Melissa L O'CONNOR; Elise G VALDÉS; Theresa A ZESIEWICZ; Ergun Y UC

doi:10.1212/WNL.0b013e3182a823ba

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Randomized trial of cognitive speed of processing training in Parkinson disease

Journal article

Open access

Peer reviewed

Randomized trial of cognitive speed of processing training in Parkinson disease

Jerri D EDWARDS, Robert A HAUSER, Melissa L O'CONNOR, Elise G VALDÉS, Theresa A ZESIEWICZ and Ergun Y UC

Neurology, Vol.81(15), pp.1284-1290

2013

DOI: 10.1212/WNL.0b013e3182a823ba

PMCID: PMC3806923

PMID: 24014503

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https://europepmc.org/articles/pmc3806923View

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Abstract

Objective: To examine the efficacy of cognitive speed of processing training (SOPT) among individuals with Parkinson disease (PD). Moderators of SOPT were also examined. Methods: Eighty-seven adults, 40 years of age or older, with a diagnosis of idiopathic PD in Hoehn & Yahr stages 1-3 and on a stable medication regimen were randomized to either 20 hours of self-administered SOPT (using InSight software) or a no-contact control condition. Participants were assessed at baseline and after 3 months of training (or an equivalent delay). The primary outcome measure was useful field of view test (UFOV) performance, and secondary outcomes included cognitive self-perceptions and depressive symptoms. Results: Results indicated that participants randomized to SOPT experienced significantly greater improvements on UFOV performance relative to controls, Wilks λ = 0.938, F 1,72 = 4.79, p = 0.032, partial η(2) = 0.062. Findings indicated no significant effect of training on secondary outcomes, Wilks λ = 0.987, F2,70 < 1, p = 0.637, partial η(2) = 0.013. Conclusions: Patients with mild to moderate stage PD can self-administer SOPT and improve their cognitive speed of processing, as indexed by UFOV (a robust predictor of driving performance in aging and PD). Further research should establish if persons with PD experience longitudinal benefits of such training and if improvements translate to benefits in functional activities such as driving. Classification of evidence: This study provides Class III evidence that SOPT improves UFOV performance among persons in the mild to moderate stages of PD.

Neurology

Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases

Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy

Biological and medical sciences

Nervous system as a whole

Medical sciences

Nervous system (semeiology, syndromes)

Details

Title: Subtitle: Randomized trial of cognitive speed of processing training in Parkinson disease
Creators: Jerri D EDWARDS - School of Aging Studies, University of South Florida, Tampa, United States
Robert A HAUSER - Department of Neurology, University of South Florida, Tampa, United States
Melissa L O'CONNOR - Department of Human Development and Family Science, North Dakota State University, Fargo, United States
Elise G VALDÉS - School of Aging Studies, University of South Florida, Tampa, United States
Theresa A ZESIEWICZ - Department of Neurology, University of South Florida, Tampa, United States
Ergun Y UC - Department of Neurology, University of Iowa, Iowa City, United States
Resource Type: Journal article
Publication Details: Neurology, Vol.81(15), pp.1284-1290
DOI: 10.1212/WNL.0b013e3182a823ba
PMID: 24014503
PMCID: PMC3806923
NLM abbreviation: Neurology
ISSN: 0028-3878
eISSN: 1526-632X
Publisher: Lippincott Williams & Wilkins; Hagerstown, MD
Language: English
Date published: 2013
Academic Unit: Neurology
Record Identifier: 9984013110402771

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