Journal article
Randomized trial of pentoxifylline and vitamin E vs standard follow-up after breast irradiation to prevent breast fibrosis, evaluated by tissue compliance meter
International journal of radiation oncology, biology, physics, Vol.85(3), pp.604-608
03/01/2013
DOI: 10.1016/j.ijrobp.2012.06.042
PMID: 22846413
Abstract
To conduct a randomized clinical trial to determine whether the combination of pentoxifylline (PTX) and vitamin E given for 6 months after breast/chest wall irradiation effectively prevents radiation-induced fibrosis (RIF).
Fifty-three breast cancer patients with localized disease were enrolled and randomized to treatment with oral PTX 400 mg 3 times daily and oral vitamin E 400 IU daily for 6 months after radiation (n=26), or standard follow up (n=27). Tissue compliance meter (TCM) measurements were obtained at 18 months to compare tissue compliance in the irradiated and untreated breast/chest wall in treated subjects and controls. Measurements were obtained at 2 mirror image sites on each breast/chest wall, and the average difference in tissue compliance was scored. Differences in TCM measurements were compared using a t test. Subjects were followed a minimum of 2 years for local recurrence, disease-free survival, and overall survival.
The mean difference in TCM measurements in the 2 groups was 0.88 mm, median of 1.00 mm (treated) and 2.10 mm, median of 2.4 mm (untreated). The difference between the 2 groups was significant (P=.0478). Overall survival (100% treated, 90.6% controls at 5 years) and disease-free survival (96.2% treated, 86.8% controls at 5 years) were not significantly different in the 2 groups.
This study of postirradiation breast cancer patients treated with PTX/vitamin E or standard follow-up indicated a significant difference in radiation-induced fibrosis as measured by TCM. There was no observed impact on local control or survival within the first 2 years of follow-up. The treatment was safe and well tolerated. Pentoxifylline/vitamin E may be clinically useful in preventing fibrosis after radiation in high-risk patients.
Details
- Title: Subtitle
- Randomized trial of pentoxifylline and vitamin E vs standard follow-up after breast irradiation to prevent breast fibrosis, evaluated by tissue compliance meter
- Creators
- Geraldine Jacobson - Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA. geraldine-jacobson@uiowa.eduSudershan BhatiaBrian J SmithAnna M ButtonKellie BodekerJohn Buatti
- Resource Type
- Journal article
- Publication Details
- International journal of radiation oncology, biology, physics, Vol.85(3), pp.604-608
- DOI
- 10.1016/j.ijrobp.2012.06.042
- PMID
- 22846413
- NLM abbreviation
- Int J Radiat Oncol Biol Phys
- ISSN
- 0360-3016
- eISSN
- 1879-355X
- Publisher
- Elsevier Inc; United States
- Language
- English
- Date published
- 03/01/2013
- Academic Unit
- Biostatistics; Radiation Oncology; Neurosurgery; Otolaryngology; Holden Comprehensive Cancer Center
- Record Identifier
- 9983997337402771
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