Journal article
Rapid Characterization of Solid Tumors Using Resonant Sensors
ACS omega, Vol.7(36), pp.32690-32700
09/13/2022
DOI: 10.1021/acsomega.2c04345
PMCID: PMC9476530
PMID: 36119978
Abstract
Cancer continues to be a significant cause of non-traumatic pediatric mortality. Diagnosis of pediatric solid tumors is paramount to prescribing the correct treatment regimen. Recent efforts have focused on non-invasive methods to obtain tumor tissues, but one of the challenges encountered is the ability to obtain an adequate amount of viable tissue. In this study, a wireless, inductor-capacitor (LC) sensor was employed to detect relative permittivity of pediatric tumor tissues. There is a comparison of resonant frequencies of tumor tissues between live versus dead tissues, the primary tumor tissue versus tissue from the organs of origin or metastasis, and treated versus untreated tumors. The results show significant shifts in resonant frequencies between the comparison groups. Dead tissues demonstrated a significant shift in resonant frequencies compared to alive tissues. There were significant differences between the resonant frequencies of normal tissues versus tumor tissues. Resonant frequencies were also significantly different between primary tumors compared to their respective metastases. These data indicate that there are potential clinical applications of LC technology in the detection and diagnosis of pediatric solid tumors.
Details
- Title: Subtitle
- Rapid Characterization of Solid Tumors Using Resonant Sensors
- Creators
- Andee M. Beierle - University of Alabama at BirminghamColin H. Quinn - University of Alabama at BirminghamHooper R. Markert - University of Alabama at BirminghamAdam Carr - Iowa State UniversityRaoud Marayati - University of Alabama at BirminghamLaura Bownes - University of Alabama at BirminghamSara Claire Hutchins - University of Alabama at BirminghamJerry E. Stewart - University of Alabama at BirminghamBenjamin Hill - Childrens Hosp Alabama, Div Pathol, Birmingham, AL 35233 USAMichael Ohlmeyer - Atux Iskay LLC, Plainsboro, NJ 08536 USANigel F. Reuel - Iowa State UniversityElizabeth A. Beierle - University of Alabama at Birmingham
- Resource Type
- Journal article
- Publication Details
- ACS omega, Vol.7(36), pp.32690-32700
- Publisher
- Amer Chemical Soc
- DOI
- 10.1021/acsomega.2c04345
- PMID
- 36119978
- PMCID
- PMC9476530
- ISSN
- 2470-1343
- eISSN
- 2470-1343
- Number of pages
- 11
- Grant note
- Sid Strong Foundation 1827578 / National Institutes of Health under the Medical Scientist Training Program; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 5T32GM008361 / National Cancer Institute of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) T32 CA229102 / Kaul Pediatric Research Foundation Elaine Roberts Foundation National Science Foundation Industrial Innovation and Partnerships PFI-RP Open Hands Overflowing Hearts
- Language
- English
- Date published
- 09/13/2022
- Academic Unit
- Stead Family Department of Pediatrics; Hematology/Oncology
- Record Identifier
- 9984701643302771
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