Journal article
Rapid HIV testing and prevention of perinatal HIV transmission in high-risk maternity hospitals in St. Petersburg, Russia
American journal of obstetrics and gynecology, Vol.198(2), pp.183.e1-183.e7
02/01/2008
DOI: 10.1016/j.ajog.2007.09.005
PMID: 18226620
Abstract
OBJECTIVE: The purpose of this study was to evaluate the effectiveness of a human immunodeficiency virus (HIV) rapid testing (RT) program.
STUDY DESIGN: From April 13, 2004, to April 13, 2005, pregnant women at 2 high-risk maternity hospitals with no or incomplete HIV testing results (negative tests at <34 weeks, none thereafter) were offered point-of-care RT, with antiretroviral prophylaxis for RT-positive women and their infants.
RESULTS: Overall, 89.2% of eligible women (3671/4117) underwent RT, of whom 90.4% received results before delivery. HIV seroprevalence among all women who underwent RT was 2.7% (100/3671 women); among previously untested women, seroprevalence was 6.5% 90/1375 women); the incidence of HIV seroconversion among women with previous negative tests during pregnancy was 0.4% (10/2296 women). After adjustment, the main predictor of receiving RT results after delivery was late admission. Among HIV-exposed infants, 97.9% (92/94) received prophylaxis; 61.7% (58/94) had available follow-up data, and 8.6% (5/58) met criteria for definitive or presumptive HIV infection.
CONCLUSION: The RT program achieved timely detection of HIV-infected women in labor with unknown HIV status and effectively prevented perinatal HIV transmission.
Details
- Title: Subtitle
- Rapid HIV testing and prevention of perinatal HIV transmission in high-risk maternity hospitals in St. Petersburg, Russia
- Creators
- Dmitry M. Kissin - Centers for Disease Control and PreventionNatalia Akatova - Elizabeth Glaser Pediat AIDS Fdn Implementat Gran, St Petersburg, RussiaAza G. Rakhmanova - City Clinical Oncology CenterElena N. Vinogradova - City Clinical Oncology CenterEvgeny E. Voronin - Republican Center for the Prevention and Control of AIDS and Infectious DiseasesDenise J. Jamieson - Centers for Disease Control and PreventionM. Kathleen Glynn - Centers for Disease Control and PreventionAlexey Yakovlev - Botkin HospitalJoanna Robinson - Elizabeth Glaser Pediatric AIDS FoundationWilliam C. Miller - University of North Carolina at Chapel HillSusan Hillis - Centers for Disease Control and Prevention
- Resource Type
- Journal article
- Publication Details
- American journal of obstetrics and gynecology, Vol.198(2), pp.183.e1-183.e7
- Publisher
- Elsevier
- DOI
- 10.1016/j.ajog.2007.09.005
- PMID
- 18226620
- ISSN
- 0002-9378
- eISSN
- 1097-6868
- Number of pages
- 7
- Language
- English
- Date published
- 02/01/2008
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446440702771
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