Journal article
Rapid Sequence Intubation, is it Time to Find an Alternative Induction Agent? A Narrative Review
Journal of pharmacy practice, Vol.37(4), pp.977-984
08/2024
DOI: 10.1177/08971900231197501
Abstract
OBJECTIVETo review the efficacy, safety, and place in therapy of fentanyl as an induction agent for rapid sequence intubation (RSI) in critically ill patients. DATA SOURCESA comprehensive search of PubMed, EMBASE, and clinical trial registries (1964-June 2021) was performed utilizing the keywords fentanyl, rapid sequence intubation, intubation, induction, anesthesia, hemodynamics, operating room (OR), and emergency. STUDY SELECTION AND DATA EXTRACTIONOnly primary literature evaluating fentanyl in combination with a sedative or as the sole induction agent was included in the final analysis. Primary literature included peer-reviewed publications and results posted on ClinicalTrials.gov actively recruiting participants. DATA SYNTHESISFentanyl has been used for decades as an adjunct, and sole induction agent in the OR. Questions surrounding the use of fentanyl as a sole induction agent include optimal dosing and safety in critically ill patients as evaluation in non-OR settings remain limited. RELEVANCE TO PATIENT CARE AND CLINICAL PRACTICECommonly used induction agents (eg, etomidate and ketamine) are associated with adverse events that may increase risk of morbidity and mortality. Fentanyl, a high-potency opioid could serve as an alternative induction agent for RSI due to its neutral hemodynamic response and fast onset of action. This paper compiles and describes existing data on the use of fentanyl as an induction agent for RSI. CONCLUSIONFentanyl in combination with sedatives provides optimal intubating conditions with minimal impact on hemodynamic parameters. Future studies should focus on safety and impact of awareness during paralysis before fentanyl can be considered as a sole induction agent.
Details
- Title: Subtitle
- Rapid Sequence Intubation, is it Time to Find an Alternative Induction Agent? A Narrative Review
- Creators
- Brett A FaineElisabeth CarrollArchit SharmaNicholas Mohr
- Resource Type
- Journal article
- Publication Details
- Journal of pharmacy practice, Vol.37(4), pp.977-984
- DOI
- 10.1177/08971900231197501
- eISSN
- 1531-1937
- Language
- English
- Electronic publication date
- 08/18/2023
- Date published
- 08/2024
- Academic Unit
- Epidemiology; Emergency Medicine; Pharmacy Practice and Science; Anesthesia; Injury Prevention Research Center
- Record Identifier
- 9984455957502771
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