Journal article
Rapid adaptation of central pathways explains the suppressed baroreflex with aging
Neurobiology of aging, Vol.12(5), pp.601-604
1991
DOI: 10.1016/0197-4580(91)90092-X
PMID: 1770991
Abstract
Aging is associated with suppressed baroreflex function. Renal sympathetic nerve activity was recorded from young (1 year) and old beagles (11 years) during a step rise in isolated carotid sinus pressure. An abrupt increase in pressure resulted in a significant and similar inhibition of efferent nerve activity in both groups, but the inhibition was not sustained in the old as compared with the young animals. The escape from sympathetic inhibition in the old could not be explained by a decline of input from sensory baroreceptor neurons. Thus the defect in the aged animals is caused by a rapid adaptation of central baroreflex neurons to the baroreceptor input instead of a lack of responsiveness of these neurons, suggesting a functional rather than a structural impairment.
Details
- Title: Subtitle
- Rapid adaptation of central pathways explains the suppressed baroreflex with aging
- Creators
- George HajduczokMark W ChapleauFrancois M Abboud
- Resource Type
- Journal article
- Publication Details
- Neurobiology of aging, Vol.12(5), pp.601-604
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0197-4580(91)90092-X
- PMID
- 1770991
- ISSN
- 0197-4580
- eISSN
- 1558-1497
- Language
- English
- Date published
- 1991
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025670202771
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