Journal article
Rapid adipose deposition with mood disorders
Annals of clinical psychiatry, Vol.27(4), pp.283-288
11/2015
PMCID: PMC4696501
PMID: 26554369
Abstract
Background: Persons with bipolar disorder represent a high-risk group for obesity, but little is known about the time course by which weight gain occurs in bipolar disorder.
Methods: We prospectively studied changes in fat distribution using dual-energy x-ray absorptiometry in relationship to medication exposure and mood symptom burden in 36 participants with bipolar disorder. We assessed the relationship between prior medication exposure and course of illness with adiposity measures at baseline (N = 36) and at 6-month follow-up (N = 22).
Results: At baseline, greater adiposity was associated with advanced age and female sex, not retrospectively assessed symptom course or medication exposure (past 2 years). Over 6 months of prospective follow-up, participants developed greater adiposity (fat mass index +0.82 kg/m(²), P = .007; visceral fat area +8.6 cm(²), P = .02; total percent fat +1.6%, P = .02). Manic symptomatology, not antipsychotic exposure, was related to the increased adiposity.
Conclusions: Acute exacerbations of mood disorders appear to represent high-risk periods for adipose deposition. Obesity prevention efforts may be necessary during acute exacerbations.
Details
- Title: Subtitle
- Rapid adipose deposition with mood disorders
- Creators
- Jess G Fiedorowicz - University of Iowa, PsychiatryLorick E Andersen - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, 52242Jane E Persons - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, Iowa, 52242Chadi Calarge - University of Iowa, Psychiatry
- Resource Type
- Journal article
- Publication Details
- Annals of clinical psychiatry, Vol.27(4), pp.283-288
- PMID
- 26554369
- PMCID
- PMC4696501
- ISSN
- 1040-1237
- eISSN
- 1547-3325
- Language
- English
- Date published
- 11/2015
- Academic Unit
- Psychiatry; Epidemiology; Iowa Neuroscience Institute
- Record Identifier
- 9984071732002771
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