Journal article
Rapid detection of antibiotic-resistant organism carriage for infection prevention
Clinical infectious diseases, Vol.56(11), pp.1614-1620
06/2013
DOI: 10.1093/cid/cit038
PMID: 23362298
Abstract
Rapid detection of multidrug-resistant organism (MDRO) carriers could help reduce MDRO infections by allowing for faster institution of prevention measures. However, improving the turnaround time (TAT) of a test requires attention to more than the analytic TAT, and will only occur if postanalytic processes (test reporting and care interventions) are also rapid and efficient. Obstacles to rapid MDRO test development include complex evolving resistance mechanisms, performance directly on mixed samples (eg, nares, stool), and adaptation of new methods for routine clinical diagnostic use. Existing data to support the clinical utility of rapid detection (vs standard culture methods) are scant. For these reasons, rapid detection of MDRO carriers remains a work in progress. Future efforts should be on developing rapid tests to detect multidrug-resistant gram-negative rods, particularly those harboring β-lactamases, and on performing clinical trials to determine how best to incorporate rapid detection of MDRO carriage into healthcare-associated infection prevention efforts.
Details
- Title: Subtitle
- Rapid detection of antibiotic-resistant organism carriage for infection prevention
- Creators
- Daniel J Diekema - University of Iowa Carver College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA. daniel-diekema@uiowa.eduMichael A Pfaller
- Resource Type
- Journal article
- Publication Details
- Clinical infectious diseases, Vol.56(11), pp.1614-1620
- Publisher
- United States
- DOI
- 10.1093/cid/cit038
- PMID
- 23362298
- ISSN
- 1058-4838
- eISSN
- 1537-6591
- Language
- English
- Date published
- 06/2013
- Academic Unit
- Infectious Diseases; Epidemiology; Pathology; Internal Medicine
- Record Identifier
- 9983986374302771
Metrics
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