Journal article
Rapid development of severe hyperplastic gastritis with gastric epithelial dedifferentiation in Helicobacter felis-infected IL-10(-/-) mice
The American journal of pathology, Vol.152(5), pp.1377-1386
05/1998
PMCID: PMC1858590
PMID: 9588906
Abstract
Interleukin (IL)-10 is a potent anti-inflammatory and immune-regulatory cytokine. Mice deficient in IL-10 production (IL-10(-/-)) develop a spontaneous inflammatory bowel disease, indicating that IL-10 is an important regulator of the mucosal immune response in vivo. To study the role of IL-10 in the host response to gastric Helicobacter infection, stomachs of IL-10(-/-) and wild-type mice were colonized with Helicobacter felis, as a model of human H. pylori infection. Within 4 weeks of H. felis infection, wild-type mice develop a mild, focal chronic gastritis. In contrast, H. felis-infected IL-10(-/-) mice develop a severe hyperplastic gastritis, characterized by a dense, predominantly mononuclear cell inflammation of the mucosa and submucosa and epithelial cell proliferation and dedifferentiation. Within 4 weeks of H. felis infection, there are striking alterations in the character of the gastric epithelium from IL-10(-/-) mice, including a profound loss of parietal and chief cells, focal de novo production of acidic mucins, and marked epithelial proliferation with disordered epithelial architecture. These findings indicate that, in the absence of IL-10, the inflammatory and immunological responses of the murine host to gastric colonization with Helicobacter is a rapidly evolving pathological process with features that mimic those associated with H. pylori infection in humans. H. felis-infected IL-10(-/-) mice may provide a model with which to investigate the cellular and molecular changes that stem from gastric infection with H. pylori.
Details
- Title: Subtitle
- Rapid development of severe hyperplastic gastritis with gastric epithelial dedifferentiation in Helicobacter felis-infected IL-10(-/-) mice
- Creators
- D. J Berg - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USAN. A Lynch - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USAR. G Lynch - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USAD. M Lauricella - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
- Resource Type
- Journal article
- Publication Details
- The American journal of pathology, Vol.152(5), pp.1377-1386
- PMID
- 9588906
- PMCID
- PMC1858590
- ISSN
- 0002-9440
- eISSN
- 1525-2191
- Language
- English
- Date published
- 05/1998
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984094590702771
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