Journal article
Rapid eye movement sleep patterns of brain activation and deactivation occur within unique functional networks
Human brain mapping, Vol.41(14), pp.3984-3992
10/01/2020
DOI: 10.1002/hbm.25102
PMID: 32573885
Abstract
Rapid eye movement (REM) sleep is a paradoxical state where the individual appears asleep while the electroencephalogram pattern resembles that of wakefulness. Regional differences in brain metabolism have been observed during REM sleep compared to wakefulness, but it is not known whether the spatial distribution of metabolic differences corresponds to known functional networks in the brain. Here, we use a combination of techniques to evaluate the networks associated with sites of REM sleep activation and deactivation from previously published positron emission tomography studies. We use seed‐based functional connectivity from healthy adults acquired during quiet rest to show that REM‐activation regions are functionally connected in a network that includes retrosplenial cingulate cortex, parahippocampal gyrus, and extrastriate visual cortices, corresponding to components of the default mode network and visual networks. Regions deactivated during REM sleep localize to right‐lateralized fronto‐parietal and salience networks. A negatively correlated relationship was observed between REM‐activation and deactivation networks. Together, these findings show that regional activation and deactivation patterns of REM sleep tend to occur in distinct functional connectivity networks that are present during wakefulness, providing insights regarding the differential contributions of brain regions to the distinct subjective experiences that occur during REM sleep (dreaming) relative to wakefulness.
Details
- Title: Subtitle
- Rapid eye movement sleep patterns of brain activation and deactivation occur within unique functional networks
- Creators
- Brandt D Uitermarkt - University of Iowa Hospitals and ClinicsJoel Bruss - University of Iowa Hospitals and ClinicsKai Hwang - University of Iowa Hospitals and ClinicsAaron D Boes - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Human brain mapping, Vol.41(14), pp.3984-3992
- DOI
- 10.1002/hbm.25102
- PMID
- 32573885
- NLM abbreviation
- Hum Brain Mapp
- ISSN
- 1065-9471
- eISSN
- 1097-0193
- Publisher
- John Wiley & Sons, Inc; Hoboken, USA
- Language
- English
- Date published
- 10/01/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Psychiatry; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984070149102771
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