Journal article
Rapid high-resolution three-dimensional mapping of T-1 and age-dependent variations in the non-human primate brain using magnetization-prepared rapid gradient-echo (MPRAGE) sequence
NeuroImage (Orlando, Fla.), Vol.56(3), pp.1154-1163
06/01/2011
DOI: 10.1016/j.neuroimage.2011.02.075
PMCID: PMC3085577
PMID: 21376814
Abstract
The use of quantitative T-1 mapping in neuroscience and neurology has raised strong interest in the development of T-1-mapping techniques that can measure T-1 in the whole brain, with high accuracy and precision and within short imaging and computation times. Here, we present a new inversion-recovery (IR) based T-1-mapping method using a standard 3D magnetization-prepared rapid gradient-echo (MPRAGE) sequence. By varying only the inversion time (TI), but keeping other parameters constant. MPRAGE image signals become linear to exp( -TI/T-1), allowing for accurate T-1 estimation without flip angle correction. We also show that acquiring data at just 3 TIs, with the three different TI values optimized, gives maximum T-1 precision per unit time, allowing for new efficient approaches to measure and compute T-1. We demonstrate the use of our method at 7 T to obtain 3D T-1 maps of the whole brain in common marmosets at 0.60 mm resolution and within 11 min. T-1 maps from the same individuals were highly reproducible across different days. Across subjects, the peak of cerebral gray matter T-1 distribution was 1735 +/- 52 ms, and the lower edge of cerebral white matter T-1 distribution was 1270 +/- 43 ms. We found a significant decrease of T-1 in both gray and white matter of the marmoset brain with age over a span of 14 years, in agreement with previous human studies. This application illustrates that MPRAGE-based 3D T-1 mapping is rapid, accurate and precise, and can facilitate high-resolution anatomical studies in neuroscience and neurological diseases. Published by Elsevier Inc.
Details
- Title: Subtitle
- Rapid high-resolution three-dimensional mapping of T-1 and age-dependent variations in the non-human primate brain using magnetization-prepared rapid gradient-echo (MPRAGE) sequence
- Creators
- Junjie V. Liu - National Institute of Neurological Disorders and StrokeNicholas A. Bock - National Institute of Neurological Disorders and StrokeAfonso C. Silva - National Institute of Neurological Disorders and Stroke
- Resource Type
- Journal article
- Publication Details
- NeuroImage (Orlando, Fla.), Vol.56(3), pp.1154-1163
- DOI
- 10.1016/j.neuroimage.2011.02.075
- PMID
- 21376814
- PMCID
- PMC3085577
- NLM abbreviation
- Neuroimage
- ISSN
- 1053-8119
- eISSN
- 1095-9572
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- NINDS, National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) ZIANS003041 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Language
- English
- Date published
- 06/01/2011
- Academic Unit
- Neurology
- Record Identifier
- 9984302200002771
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