Journal article
Rapid interaction of tetraethylammonium with delayed K + channel in mammalian brain neuron
Neuroscience letters, Vol.131(2), pp.153-155
1991
DOI: 10.1016/0304-3940(91)90601-O
PMID: 1762690
Abstract
In order to study the rapidity of interaction between tetraethylammonium (TEA) and the delayed K
+ channel of the mammalian brain neuron, TEA was applied to isolated rat hippocampal pyramidal neurons in a time-controlled sequence with a voltage step using a concentration clamp technique. TEA at a concentration of 30 mM, externally applied, started to decrease the delayed K
+ current (
I
KD) without any detectable delay after the onset of the drug application. The inhibitory action of TEA reached a steady state within 10 ms while the full recovery from the inhibition required 20–30 ms after removing TEA from the external solution. Ba
2+ at a concentration of 30 mM also reduced the
I
KD without any detectable delay. However, it took 40–60 s to reach the steady state of inhibition. Full recovery from the inhibition by Ba
2+ was obtained around 60 s after removal of Ba
2+ from the external solution. It is suggested that the interaction of TEA with the delayed K
+ channel is much faster than that of Ba
2+.
Details
- Title: Subtitle
- Rapid interaction of tetraethylammonium with delayed K + channel in mammalian brain neuron
- Creators
- Yasuo OyamaNobutoshi HarataNorio Akaike
- Resource Type
- Journal article
- Publication Details
- Neuroscience letters, Vol.131(2), pp.153-155
- Publisher
- Elsevier Ireland Ltd
- DOI
- 10.1016/0304-3940(91)90601-O
- PMID
- 1762690
- ISSN
- 0304-3940
- eISSN
- 1872-7972
- Language
- English
- Date published
- 1991
- Academic Unit
- Molecular Physiology and Biophysics
- Record Identifier
- 9984025434002771
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