Journal article
Rapid rest/stress regadenoson ungated perfusion CMR for detection of coronary artery disease in patients with atrial fibrillation
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, Vol.33(11), pp.1781-1788
11/01/2017
DOI: 10.1007/s10554-017-1168-1
PMCID: PMC6267777
PMID: 28528431
Abstract
Cardiovascular magnetic resonance (CMR) perfusion has been established as a useful imaging modality for the detection of coronary artery disease (CAD). However, there are several limitations when applying standard, ECG-gated stress/rest perfusion CMR to patients with atrial fibrillation (AF). In this study we investigate an approach with no ECG gating and a rapid rest/stress perfusion protocol to determine its accuracy for detection of CAD in patients with AF. 26 patients with AF underwent a rapid rest/regadenoson stress CMR perfusion imaging protocol, and all patients had X-ray coronary angiography. An ungated radial myocardial perfusion sequence was used. Imaging protocol included: rest perfusion image acquisition, followed nearly immediately by administration of regadenoson to induce hyperemia, 60 s wait, and stress image acquisition. CMR perfusion images were interpreted by three blinded readers as normal or abnormal. Diagnostic accuracy was evaluated by comparison to X-ray angiography. 21 of the CMR rest/stress perfusion scans were negative, and 5 were positive by angiography criteria. Majority results of the ungated datasets from all of the readers showed a sensitivity, specificity and accuracy of 80, 100 and 96%, respectively, for detection of CAD. An ungated, rapid rest/stress regadenoson perfusion CMR protocol appears to be useful for the diagnosis of obstructive CAD in patients with AF.
Details
- Title: Subtitle
- Rapid rest/stress regadenoson ungated perfusion CMR for detection of coronary artery disease in patients with atrial fibrillation
- Creators
- Erik T. Bieging - University of UtahI. Haider - University of UtahG. Adluru - University of UtahL. Chang - University of UtahP. Suksaranjit - University of UtahD. Likhite - University of UtahA. Shaaban - University of UtahL. Jensen - University of UtahB. D. Wilson - University of UtahC. J. McGann - Swedish Medical CenterE. DiBella - University of Utah
- Resource Type
- Journal article
- Publication Details
- INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, Vol.33(11), pp.1781-1788
- DOI
- 10.1007/s10554-017-1168-1
- PMID
- 28528431
- PMCID
- PMC6267777
- NLM abbreviation
- Int J Cardiovasc Imaging
- ISSN
- 1569-5794
- eISSN
- 1573-0743
- Publisher
- Springer Nature
- Number of pages
- 8
- Grant note
- R01HL113224 / National Heart, Lung, and Blood Institute of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Astellas Pharma; Astellas Pharmaceuticals R01HL113224 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 11/01/2017
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984359940402771
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