Journal article
Rapid vacuum sintering: A novel technique for fabricating fluorapatite ceramic scaffolds for bone tissue engineering
Journal of biomedical materials research. Part B, Applied biomaterials, Vol.106(1), pp.291-299
01/2018
DOI: 10.1002/jbm.b.33825
PMCID: PMC5534389
PMID: 28135032
Abstract
Macroporous bioceramic scaffolds are often fabricated via the foam replica technique, based on polymeric foam impregnation with a glass slurry, followed by slow heat treatment to allow for drying, polymeric burnout, and sintering of the glass particles. As a consequence, the process is time consuming and complicated by concurrent crystallization of the glass, often leading to incomplete sintering. Our goal was to investigate the effect of heating rate on sintering behavior, architecture, and mechanical properties of fluorapatite-based glass and glass-ceramic scaffolds. Glass scaffolds were prepared and sintered by rapid vacuum sintering (RVS) at 785°C under vacuum at a fast heating rate (55°C/min.) or without vacuum at a slow heating rate (2°C/min.). Two additional groups were further crystallized at 775°C/1 h. XRD confirmed the presence of fluorapatite for crystallized scaffolds. All groups presented interconnected porosity with a pore size in the 500 μm range. Scaffolds produced by RVS exhibited an excellent degree of sintering while scaffolds produced by slow sintering were incompletely sintered. The mean compressive strength was significantly higher for the RVS groups (1.52 ± 0.55 and 1.72 ± 0.61 MPa) compared to the slow-sintered groups (0.54 ± 0.30 and 0.45 ± 0.26 MPa). Meanwhile, the total production time was reduced by more than 12 h by using the RVS technique. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 291-299, 2018.
Details
- Title: Subtitle
- Rapid vacuum sintering: A novel technique for fabricating fluorapatite ceramic scaffolds for bone tissue engineering
- Creators
- Isabelle Denry - Department of Prosthodontics, University of Iowa College of Dentistry, Iowa City, IowaOurania-Menti Goudouri - Iowa Institute for Oral Health Research, University of Iowa College of Dentistry, Iowa City, IowaJeffrey Harless - Iowa Institute for Oral Health Research, University of Iowa College of Dentistry, Iowa City, IowaJulie A Holloway - Department of Prosthodontics, University of Iowa College of Dentistry, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of biomedical materials research. Part B, Applied biomaterials, Vol.106(1), pp.291-299
- Publisher
- United States
- DOI
- 10.1002/jbm.b.33825
- PMID
- 28135032
- PMCID
- PMC5534389
- ISSN
- 1552-4973
- eISSN
- 1552-4981
- Grant note
- R01 DE019972 / NIDCR NIH HHS
- Language
- English
- Date published
- 01/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Prosthodontics; Dental Research
- Record Identifier
- 9984066000102771
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