Journal article
Rare Histological Variants of Prostate Adenocarcinoma: A National Cancer Database Analysis
The Journal of urology, Vol.204(2), pp.260-265
08/01/2020
DOI: 10.1097/JU.0000000000001011
PMID: 32141804
Abstract
Purpose: The American Joint Committee on Cancer recognizes 6 rare histological variants of prostate adenocarcinoma. We describe the contemporary presentation and overall survival of these rare variants.
Materials and Methods: We examined 1,345,618 patients who were diagnosed with prostate adenocarcinoma between 2004 and 2015 within the National Cancer Database. We focused on the variants mucinous, ductal, signet ring cell, adenosquamous, sarcomatoid and neuroendocrine. Characteristics at presentation for each variant were compared with nonvariant prostate adenocarcinoma. Cox regression was used to study the impact of histological variant on overall mortality.
Results: Few (0.38%) patients presented with rare variant prostate adenocarcinoma. All variants had higher clinical tumor stage at presentation than nonvariant (all p <0.001). Metastatic disease was most common with neuroendocrine (62.9%), followed by sarcomatoid (33.3%), adenosquamous (31.1%), signet ring cell (10.3%) and ductal (9.8%), compared to 4.2% in nonvariant (all p <0.001). Metastatic disease in mucinous (3.3%) was similar to nonvariant (p = 0.2). Estimated 10-year overall survival was highest in mucinous (78.0%), followed by nonvariant (71.1%), signet ring cell (56.8%), ductal (56.3%), adenosquamous (20.5%), sarcomatoid (14.6%) and neuroendocrine (9.1%). At multivariable analysis, mortality was higher in ductal (HR 1.38, p <0.001), signet ring cell (HR 1.53, p <0.01), neuroendocrine (HR 5.72, p <0.001), sarcomatoid (HR 5.81, p <0.001) and adenosquamous (HR 9.34, p <0.001) as compared to nonvariant.
Conclusions: Neuroendocrine, adenosquamous, sarcomatoid, signet ring cell and ductal variants more commonly present with metastases. All variants present with higher local stage than nonvariant. Neuroendocrine is associated with the worst and mucinous with the best overall survival.
Details
- Title: Subtitle
- Rare Histological Variants of Prostate Adenocarcinoma: A National Cancer Database Analysis
- Creators
- Chandler Bronkema - Henry Ford HospitalSohrab Arora - Henry Ford HospitalAkshay Sood - Henry Ford Hosp, Vattikuti Urol Inst, Detroit, MI 48202 USADeepansh Dalela - Henry Ford HospitalJacob Keeley - Henry Ford HospitalAlex Borchert - Henry Ford HospitalLee Baumgarten - Henry Ford HospitalCraig G. Rogers - Henry Ford HospitalJames O. Peabody - Henry Ford HospitalMani Menon - Henry Ford HospitalFiras Abdollah - Henry Ford Hospital
- Resource Type
- Journal article
- Publication Details
- The Journal of urology, Vol.204(2), pp.260-265
- DOI
- 10.1097/JU.0000000000001011
- PMID
- 32141804
- NLM abbreviation
- J Urol
- ISSN
- 0022-5347
- eISSN
- 1527-3792
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Language
- English
- Date published
- 08/01/2020
- Academic Unit
- Urology
- Record Identifier
- 9984949480602771
Metrics
2 Record Views