Rat Models of Diet-Induced Obesity and High Fat/Low Dose Streptozotocin Type 2 Diabetes: Effect of Reversal of High Fat Diet Compared to Treatment with Enalapril or Menhaden Oil on Glucose Utilization and Neuropathic Endpoints

Amey Holmes; Lawrence J Coppey; Eric P Davidson; Mark A Yorek

doi:10.1155/2015/307285

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Rat Models of Diet-Induced Obesity and High Fat/Low Dose Streptozotocin Type 2 Diabetes: Effect of Reversal of High Fat Diet Compared to Treatment with Enalapril or Menhaden Oil on Glucose Utilization and Neuropathic Endpoints

Journal article

Open access

Peer reviewed

Rat Models of Diet-Induced Obesity and High Fat/Low Dose Streptozotocin Type 2 Diabetes: Effect of Reversal of High Fat Diet Compared to Treatment with Enalapril or Menhaden Oil on Glucose Utilization and Neuropathic Endpoints

Amey Holmes, Lawrence J Coppey, Eric P Davidson and Mark A Yorek

Journal of diabetes research, Vol.2015, pp.307285-8

2015

DOI: 10.1155/2015/307285

PMCID: PMC4503545

PMID: 26229968

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https://doi.org/10.1155/2015/307285View

Published (Version of record) Open Access

Abstract

We examined whether reversal of high fat diet, stimulating weight loss, compared to two treatments previously shown to have beneficial effects, could improve glucose utilization and peripheral neuropathy in animal models of obesity and type 2 diabetes. Rats were fed a high fat diet and treated with a low dose of streptozotocin to create models of diet induced obesity or type 2 diabetes, respectively. Afterwards, rats were transferred to a normal diet or treated with enalapril or dietary enrichment with menhaden oil for 12 weeks. Obesity and to a greater extent type 2 diabetes were associated with impaired glucose utilization and peripheral neuropathy. Placing obese rats on a normal diet improved glucose utilization. Steatosis but not peripheral neuropathy was improved after placing obese or diabetic rats on a normal diet. Treating obese and diabetic rats with enalapril or a menhaden oil enriched diet generally improved peripheral neuropathy endpoints. In summary, dietary improvement with weight loss in obese or type 2 diabetic rats was not sufficient to correct peripheral neuropathy. These results further stress the need for discovery of a comprehensive treatment for peripheral neuropathy.

Angiotensin-Converting Enzyme Inhibitors - therapeutic use

Animals

Anti-Obesity Agents - therapeutic use

Biomarkers - blood

Diabetes Mellitus, Type 2 - complications

Diabetes Mellitus, Type 2 - diet therapy

Diabetes Mellitus, Type 2 - drug therapy

Diabetes Mellitus, Type 2 - etiology

Diabetic Neuropathies - complications

Diabetic Neuropathies - prevention & control

Diet, Fat-Restricted

Diet, High-Fat - adverse effects

Dietary Supplements

Disease Models, Animal

Enalapril - therapeutic use

Fish Oils - therapeutic use

Hypoglycemic Agents - therapeutic use

Male

Neuralgia - complications

Neuralgia - prevention & control

Non-alcoholic Fatty Liver Disease - complications

Obesity - complications

Obesity - diet therapy

Obesity - drug therapy

Obesity - etiology

Rats, Sprague-Dawley

Streptozocin - toxicity

Weight Loss - drug effects

Details

Title: Subtitle: Rat Models of Diet-Induced Obesity and High Fat/Low Dose Streptozotocin Type 2 Diabetes: Effect of Reversal of High Fat Diet Compared to Treatment with Enalapril or Menhaden Oil on Glucose Utilization and Neuropathic Endpoints
Creators: Amey Holmes - Iowa City VA Health Care System
Lawrence J Coppey - University of Iowa
Eric P Davidson - University of Iowa
Mark A Yorek - United States Department of Veterans Affairs
Resource Type: Journal article
Publication Details: Journal of diabetes research, Vol.2015, pp.307285-8
DOI: 10.1155/2015/307285
PMID: 26229968
PMCID: PMC4503545
NLM abbreviation: J Diabetes Res
ISSN: 2314-6745
eISSN: 2314-6753
Grant note: I01 BX001680 / BLRD VA I01 RX000889 / RRD VA
Language: English
Date published: 2015
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984359866802771

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