Journal article
Rat glioma cell line as a model for astrogliosis
Cytobios, Vol.82(328), pp.39-51
1995
PMID: 7587374
Abstract
In this investigation 9L rat glioma cells were grown on coverslips in culture, and when subjected to mechanical trauma, they were capable of mounting an astroglial response, without interaction with neurons, as evidenced by cell hypertrophy and increased immunostaining for glial fibrillary acidic protein and J1-31 antigen. It is of particular interest that this neoplastically transformed cell line is capable of mounting an astroglial response when subjected to mechanical trauma in vitro. The advantages of this model over in vivo models of central nervous system injury include the ease of reproducibility of results, and the ability to investigate molecular mechanisms under controlled conditions.
Details
- Title: Subtitle
- Rat glioma cell line as a model for astrogliosis
- Creators
- S K Malhotra - Department of Biological Sciences, University of Alberta, Edmonton, CanadaR BhatnagarT K ShnitkaJ J HerreraJ R KokeM V Singh
- Resource Type
- Journal article
- Publication Details
- Cytobios, Vol.82(328), pp.39-51
- PMID
- 7587374
- ISSN
- 0011-4529
- Language
- English
- Date published
- 1995
- Academic Unit
- Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984094658902771
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