Journal article
Rat intersubjective decisions are encoded by frequency-specific oscillatory contexts
Brain and behavior, Vol.7(6), pp.e00710-n/a
06/2017
DOI: 10.1002/brb3.710
PMCID: PMC5474713
PMID: 28638715
Abstract
It is unknown how the brain coordinates decisions to withstand personal costs in order to prevent other individuals' distress. Here we test whether local field potential (LFP) oscillations between brain regions create "neural contexts" that select specific brain functions and encode the outcomes of these types of intersubjective decisions. Rats participated in an "Intersubjective Avoidance Test" (IAT) that tested rats' willingness to enter an innately aversive chamber to prevent another rat from getting shocked. c-Fos immunoreactivity was used to screen for brain regions involved in IAT performance. Multi-site local field potential (LFP) recordings were collected simultaneously and bilaterally from five brain regions implicated in the c-Fos studies while rats made decisions in the IAT. Local field potential recordings were analyzed using an elastic net penalized regression framework. Rats voluntarily entered an innately aversive chamber to prevent another rat from getting shocked, and c-Fos immunoreactivity in brain regions known to be involved in human empathy-including the anterior cingulate, insula, orbital frontal cortex, and amygdala-correlated with the magnitude of "intersubjective avoidance" each rat displayed. Local field potential recordings revealed that optimal accounts of rats' performance in the task require specific frequencies of LFP oscillations between brain regions specific frequencies of LFP oscillations within brain regions. Alpha and low gamma coherence between spatially distributed brain regions predicts more intersubjective avoidance, while theta and high gamma coherence between a separate subset of brain regions predicts less intersubjective avoidance. Phase relationship analyses indicated that choice-relevant coherence in the alpha range reflects information passed from the amygdala to cortical structures, while coherence in the theta range reflects information passed in the reverse direction. These results indicate that the frequency-specific "neural context" surrounding brain regions involved in social cognition encodes outcomes of decisions that affect others, above and beyond signals from any set of brain regions in isolation.
Details
- Title: Subtitle
- Rat intersubjective decisions are encoded by frequency-specific oscillatory contexts
- Creators
- Jana Schaich Borg - Department of Psychiatry and Behavioral Sciences Stanford University Stanford CA USASanvesh Srivastava - Department of Statistics and Actuarial Science University of Iowa Iowa City IA USALizhen Lin - Department of Applied and Computational Mathematics and Statistics University of Notre Dame Notre Dame IN USAJoseph Heffner - Department of Psychology, Cognitive Linguistic and Psychological Sciences Brown University Providence RI USADavid Dunson - Department of Statistical Science Duke University Durham NC USAKafui Dzirasa - Department of Biomedical Engineering Duke University Durham NC USALuis de Lecea - Department of Psychiatry and Behavioral Sciences Stanford University Stanford CA USA
- Resource Type
- Journal article
- Publication Details
- Brain and behavior, Vol.7(6), pp.e00710-n/a
- DOI
- 10.1002/brb3.710
- PMID
- 28638715
- PMCID
- PMC5474713
- NLM abbreviation
- Brain Behav
- ISSN
- 2162-3279
- eISSN
- 2162-3279
- Publisher
- United States
- Grant note
- R01 MH102638 / NIMH NIH HHS
- Language
- English
- Date published
- 06/2017
- Academic Unit
- Statistics and Actuarial Science
- Record Identifier
- 9983985811102771
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