Rate of Weight Gain and Cardiometabolic Abnormalities in Children and Adolescents

Chadi A Calarge; Diqiong Xie; Jess G Fiedorowicz; Trudy L Burns; William G Haynes

doi:10.1016/j.jpeds.2012.05.051

Back

Rate of Weight Gain and Cardiometabolic Abnormalities in Children and Adolescents

Journal article

Peer reviewed

Rate of Weight Gain and Cardiometabolic Abnormalities in Children and Adolescents

Chadi A Calarge, Diqiong Xie, Jess G Fiedorowicz, Trudy L Burns and William G Haynes

The Journal of pediatrics, Vol.161(6), pp.1010-1015.e1

12/2012

DOI: 10.1016/j.jpeds.2012.05.051

PMCID: PMC3461238

PMID: 22738944

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/3461238View

Open Access

Abstract

To investigate whether the rate of weight gain is associated with cardiometabolic risk, independent of weight measured concurrently. Healthy 7- to 17-year-old risperidone-treated patients (N = 105, 88% were boys) had blood pressure, anthropometry, and laboratory tests performed. Growth history was extracted from medical records. The rate of change in age- and sex-adjusted weight and body mass index (BMI) z score after the initiation of risperidone was individually modeled. Multivariable linear regression analyses explored the association of the rate of weight or BMI z score change with cardiometabolic outcomes, independent of last measured weight or BMI z score, respectively. Following a mean of 1.9 years (SD = 1.0) of risperidone treatment, the absolute increase in weight and BMI z scores was 0.61 (SD = 0.61) and 0.62 (SD = 0.73), respectively. After controlling for the final weight z score, the rate of change in weight z score was significantly associated with final glucose (P < .04), C-peptide (P < .004), the homeostasis model assessment insulin resistance index (P < .02), high-density lipoprotein (HDL) cholesterol (P < .0001), a metabolic syndrome score (P < .005), adiponectin (P < .04), and high-sensitivity C-reactive protein (P < .04). After controlling for the final BMI z score, the rate of change in BMI z score was associated with final HDL cholesterol (P < .04), leptin (P < .03), and adiponectin (P < .04), with a suggestion of an association with the final homeostasis model assessment insulin resistance index (P < .08). Compared with weight measured concurrently, the rate of weight gain in risperidone-treated children accounts for an equal or larger share of the variance in certain cardiometabolic outcomes (eg, HDL cholesterol [ΔR2 = 8% vs ΔR2 = 11%] and high-sensitivity C-reactive protein [ΔR2 = 5% vs ΔR2 = 9%]) and may serve as a treatment target.

hsCRP

HDL

HOMA-IR

log

BMI

Details

Title: Subtitle: Rate of Weight Gain and Cardiometabolic Abnormalities in Children and Adolescents
Creators: Chadi A Calarge - Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, IA
Diqiong Xie - Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, IA
Jess G Fiedorowicz - Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, IA
Trudy L Burns - Department of Pediatrics, The University of Iowa Carver College of Medicine, Iowa City, IA
William G Haynes - Department of Internal Medicine, The University of Iowa Carver College of Medicine, Iowa City, IA
Resource Type: Journal article
Publication Details: The Journal of pediatrics, Vol.161(6), pp.1010-1015.e1
DOI: 10.1016/j.jpeds.2012.05.051
PMID: 22738944
PMCID: PMC3461238
NLM abbreviation: J Pediatr
ISSN: 0022-3476
eISSN: 1097-6833
Publisher: Mosby, Inc
Grant note: R21MH080968; K23MH085005 / National Institute of Mental Health Brain and Behavior Research Foundation RR0024979 / National Center for Research Resources
Language: English
Date published: 12/2012
Academic Unit: Psychiatry; Epidemiology; Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984065393802771

Metrics

17 Record Views

21 Times Cited - Web of Science