Journal article
Rates and Extents of Antifungal Activities of Amphotericin B, Flucytosine, Fluconazole, and Voriconazole against Candida lusitaniae Determined by Microdilution, Etest, and Time-Kill Methods
Antimicrobial agents and chemotherapy, Vol.46(2), pp.578-581
02/2002
DOI: 10.1128/AAC.46.2.578-581.2002
PMCID: PMC127046
PMID: 11796383
Abstract
Amphotericin B, flucytosine, fluconazole, and voriconazole alone and in combination were evaluated against isolates of Candida lusitaniae. MICs were determined by broth microdilution and Etest, and time-kill studies were conducted. Amphotericin B resulted in fungicidal activity against most isolates, whereas fluconazole, voriconazole, and flucytosine produced primarily fungistatic activities. The addition of flucytosine to amphotericin B resulted in a faster rate and greater extent of kill for isolates for which the MICs of amphotericin B were elevated.
Details
- Title: Subtitle
- Rates and Extents of Antifungal Activities of Amphotericin B, Flucytosine, Fluconazole, and Voriconazole against Candida lusitaniae Determined by Microdilution, Etest, and Time-Kill Methods
- Creators
- Erika J Ernst - University of IowaKeiko Yodoi - University of IowaEllen E Roling - University of IowaMichael E Klepser - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Antimicrobial agents and chemotherapy, Vol.46(2), pp.578-581
- Publisher
- American Society for Microbiology
- DOI
- 10.1128/AAC.46.2.578-581.2002
- PMID
- 11796383
- PMCID
- PMC127046
- ISSN
- 0066-4804
- eISSN
- 1098-6596
- Language
- English
- Date published
- 02/2002
- Academic Unit
- Pharmacy Practice and Science
- Record Identifier
- 9984365893002771
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